『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Furukawa T (日) (読)
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2. (英) Bai CX (日) (読)
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3. (英) Kaihara A (日) (読)
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4. (英) Ozaki E (日) (読)
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5.河野 崇
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6.中屋 豊
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7. (英) Awais M (日) (読)
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8. (英) Sato M (日) (読)
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9. (英) Umezawa Y (日) (読)
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10. (英) Kurokawa J (日) (読)
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題名 (必須): (英) Ginsenoside Re a main phytosterol of Panax ginseng activates cardiac potassium channels via a nongenomic pathway of sex hormones.  (日)    [継承]
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要約 (任意): (英) Ginseng root is one of the most popular herbs throughout the world and is believed to be a panacea and to promote longevity. It has been used as a medicine to protect against cardiac ischemia, a major cause of death in the West. We have previously demonstrated that ginsenoside Re, a main phytosterol of Panax ginseng, inhibits Ca(2+) accumulation in mitochondria during cardiac ischemia/reperfusion, which is attributable to nitric oxide (NO)-induced Ca(2+) channel inhibition and K(+) channel activation in cardiac myocytes. In this study, we provide compelling evidence that ginsenoside Re activates endothelial NO synthase (eNOS) to release NO, resulting in activation of the slowly activating delayed rectifier K(+) current. The eNOS activation occurs via a nongenomic pathway of each of androgen receptor, estrogen receptor-alpha, and progesterone receptor, in which c-Src, phosphoinositide 3-kinase, Akt, and eNOS are sequentially activated. However, ginsenoside Re does not stimulate proliferation of androgen-responsive LNCaP cells and estrogen-responsive MCF-7 cells, implying that ginsenoside Re does not activate a genomic pathway of sex hormone receptors. Fluorescence resonance energy transfer experiments with a probe, SCCoR (single cell coactivator recruitment), indicate that the lack of genomic action is attributable to failure of coactivator recruitment. Thus, ginsenoside Re acts as a specific agonist for the nongenomic pathway of sex steroid receptors, and NO released from activated eNOS underlies cardiac K(+) channel activation and protection against ischemia-reperfusion injury.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Enzyme Activation (日) (読) [継承]
4. (英) Estrogen Receptor alpha (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Fluorescence Resonance Energy Transfer (日) (読) [継承]
7. (英) Ginsenosides (日) (読) [継承]
8. (英) Guinea Pigs (日) (読) [継承]
9.心臓 (heart) [継承]
10.一酸化窒素 (nitric oxide) [継承]
11. (英) Nitric Oxide Synthase Type III (日) (読) [継承]
12. (英) Panax (日) (読) [継承]
13.リン酸化 (phosphorylation) [継承]
14. (英) Potassium Channels (日) (読) [継承]
15. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
16. (英) Receptors, Androgen (日) (読) [継承]
17. (英) Receptors, Progesterone (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Pharmacology (American Society for Pharmacology and Experimental Therapeutics)
(pISSN: 0026-895X, eISSN: 1521-0111)

ISSN (任意): 0026-895X
ISSN: 0026-895X (pISSN: 0026-895X, eISSN: 1521-0111)
Title: Molecular pharmacology
Title(ISO): Mol Pharmacol
Publisher: American Society for Pharmacology and Experimental Therapeutics
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 70 [継承]
(必須): 6 [継承]
(必須): 1916 1924 [継承]
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年月日 (必須): 西暦 2006年 9月 19日 (平成 18年 9月 19日) [継承]
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DOI (任意): 10.1124/mol.106.028134    (→Scopusで検索) [継承]
PMID (任意): 16985185    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-33751119582 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. t_furukawa.bip@mri.tmd.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Furukawa, CX Bai, A Kaihara, E Ozaki, Takashi Kawano, Yutaka Nakaya, M Awais, M Sato, Y Umezawa and J Kurokawa : Ginsenoside Re a main phytosterol of Panax ginseng activates cardiac potassium channels via a nongenomic pathway of sex hormones., Molecular Pharmacology, Vol.70, No.6, 1916-1924, 2006.
欧文冊子 ● T Furukawa, CX Bai, A Kaihara, E Ozaki, Takashi Kawano, Yutaka Nakaya, M Awais, M Sato, Y Umezawa and J Kurokawa : Ginsenoside Re a main phytosterol of Panax ginseng activates cardiac potassium channels via a nongenomic pathway of sex hormones., Molecular Pharmacology, Vol.70, No.6, 1916-1924, 2006.

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