『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162911EID:162911, Map:0, LastModified:2014年9月8日(月) 16:00:38, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[川人 伸次], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜) [継承]
2.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Akiyo Nakamura (日) 中村 明代 (読) なかむら あきよ
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2.川人 伸次 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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3.河野 崇
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[継承]
4. (英) Hossein Nazari (日) (読)
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[継承]
5.髙橋 章 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])
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[継承]
6.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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[継承]
7.中屋 豊
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[継承]
8.大下 修造
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[継承]
題名 (必須): (英) Differential Effects of Etomidate and Midazolam on Vascular Adenosine Triphosphate-sensitive Potassium Channels: Isometric Tension and Patch Clamp Studies.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. In isolated rat aorta, isometric tension was recorded to examine the anesthetic effects on vasodilator response to levcromakalim, a selective KATP channel opener. Using the patch clamp method, the anesthetic effects were also examined on the currents through (1) native vascular KATP channels, (2) recombinant KATP channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits, (3) SUR-deficient channels derived from a truncated isoform of Kir6.2 subunit (Kir6.2DeltaC36 channels), and (4) mutant Kir6.2DeltaC36 channels with reduced sensitivity to adenosine triphosphate (Kir6.2DeltaC36-K185Q channels). Etomidate (> or = 10 m), but not midazolam (up to 10 m), inhibited the levcromakalim-induced vasodilation, which was sensitive to glibenclamide (IC50: 7.21 x 10 m; maximum inhibitory concentration: 1.22 x 10 m). Etomidate (> or = 3 x 10 m), but not midazolam (up to 10 m), inhibited the native KATP channel activity in both cell-attached and inside-out configurations with IC50 values of 1.68 x 10 m and 1.52 x 10 m, respectively. Etomidate (10 m) also inhibited the activity of various types of recombinant SUR/Kir6.0KATP channels, Kir6.2DeltaC36 channels, and Kir6.2DeltaC36-K185Q channels with equivalent potency. Clinical concentrations of etomidate, but not midazolam, inhibit the KATP channel activity in vascular smooth muscle cells. The inhibition is presumably through its effects on the Kir6.0 subunit, but not on the SUR subunit, with the binding site different from adenosine triphosphate at the amino acid level.  (日)    [継承]
キーワード (推奨): 1. (英) ATP-Binding Cassette Transporters (日) (読) [継承]
2. (英) Adenosine Triphosphate (日) (読) [継承]
3. (英) Anesthetics, Intravenous (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Aorta, Thoracic (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Cromakalim (日) (読) [継承]
8. (英) Dose-Response Relationship, Drug (日) (読) [継承]
9. (英) Electrophysiology (日) (読) [継承]
10. (英) Etomidate (日) (読) [継承]
11. (英) Glyburide (日) (読) [継承]
12. (英) Isometric Contraction (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Midazolam (日) (読) [継承]
15. (英) Myocytes, Smooth Muscle (日) (読) [継承]
16. (英) Organ Culture Techniques (日) (読) [継承]
17. (英) Patch-Clamp Techniques (日) (読) [継承]
18. (英) Potassium Channels (日) (読) [継承]
19. (英) Potassium Channels, Inwardly Rectifying (日) (読) [継承]
20. (英) Rats (日) (読) [継承]
21. (英) Rats, Wistar (日) (読) [継承]
22. (英) Receptors, Drug (日) (読) [継承]
23. (英) Transfection (日) (読) [継承]
24. (英) Vasodilation (日) (読) [継承]
25. (英) Vasodilator Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 5月 初日 (平成 19年 5月 初日) [継承]
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DOI (任意): 10.1097/00000542-200703000-00016    (→Scopusで検索) [継承]
PMID (任意): 17325510    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Nakamura Akiyo, Shinji Kawahito, Takashi Kawano, Nazari Hossein, Akira Takahashi, Hiroshi Kitahata, Yutaka Nakaya and Shuzo Oshita : Differential Effects of Etomidate and Midazolam on Vascular Adenosine Triphosphate-sensitive Potassium Channels: Isometric Tension and Patch Clamp Studies., Anesthesiology, Vol.106, No.3, 515-522, 2007.
欧文冊子 ● Nakamura Akiyo, Shinji Kawahito, Takashi Kawano, Nazari Hossein, Akira Takahashi, Hiroshi Kitahata, Yutaka Nakaya and Shuzo Oshita : Differential Effects of Etomidate and Midazolam on Vascular Adenosine Triphosphate-sensitive Potassium Channels: Isometric Tension and Patch Clamp Studies., Anesthesiology, Vol.106, No.3, 515-522, 2007.

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