| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.器官病態修復医学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 黒部 裕嗣
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| 2. | 北市 隆
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| 3. | (英) Shimahara Yusuke (日) (読)
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| 4. | (英) Kanemura Takeyuki (日) (読)
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| 5. | 神原 保
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| 6. | (英) Kurushima Atsushi (日) (読)
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| 7. | 加納 正志
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| 8. | 堀 隆樹
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| 9. | 吉田 誉
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| 10. | (英) Urata Masahiro (日) (読)
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| 11. | 北川 哲也
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| ○題名 (必須): | □ | (英) Significance of Peritoneal Fluid Drainage in Management After Repair of Complex Heart Defects in Infancy (日)
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| ○副題 (任意): | □ | (英) Cytokine Dynamics In Vivo (日)
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| ○要約 (任意): | □ | (英) In vivo redundancy of pro-inflammatory cytokines results in a vicious cycle of systemic inflammatory response syndrome and low cardiac output syndrome (LOS). The purpose of this study was to elucidate the influence of peritoneal fluid (PF) drainage on cytokine dynamics in vivo and the significance of early induction for infants with LOS. Seven infants, who underwent early PF drainage to manage LOS after repair of complex heart defects under cardiopulmonary bypass, were enrolled. The serum and PF levels of the pro- and antiinflammatory cytokines, interleukin (IL)-6, -8, -10 and tumor necrosis factor (TNF)-alpha, were measured during the perioperative period. Clinical outcomes were observed simultaneously. There were no cases of early or late death, or infectious complications. Drainage volume of PF peaked just after operation, and decreased completely. The amount of proinflammatory cytokines in the PF increased for 3 days after operation. Of the proinflammatory cytokines in the PF IL-6 increased the earliest and cleared the fastest. The amount of cleared IL-8 and TNF-alpha peaked on the 3rd postoperative day and resembled the course of C-reactive protein (CRP). Serum levels of CRP and proinflammatory cytokines in patients with PF drainage decreased significantly more than those without PF drainage. Early initiation of PF drainage is useful in the postoperative critical care of infants with LOS by improving cytokine dynamics in vivo, although there are differences between the severity of patients undergoing PF drainage and those who do not. (日)
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| ○キーワード (推奨): | 1. | (英) Ascitic Fluid (日) (読)
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| 2. | (英) C-Reactive Protein (日) (読)
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| 3. | (英) Cardiac Output, Low (日) (読)
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| 4. | (英) Cardiopulmonary Bypass (日) (読)
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| 5. | 細胞質分裂 (cytokinesis)
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| 6. | (英) Drainage (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Heart Defects, Congenital (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | 小児 (infant)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Postoperative Care (日) (読)
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| 13. | (英) Postoperative Period (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
| ○ISSN (任意): | □ | 1346-9843
ISSN: 1346-9843
(pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation SocietyTitle(ISO): Circ JSupplier: 社団法人日本循環器学会Publisher: Japanese Circulation Society (NLM Catalog)
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| ○巻 (必須): | □ | 71
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 941 947
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 6月 初日 (平成 19年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1253/circj.71.941 (→Scopusで検索)
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| ○PMID (任意): | □ | 17526994 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Cardiovascular Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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