『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tsukumo Shin-ichi (日) (読)
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[継承]
2. (英) Hirose Kayo (日) (読)
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3.前川 洋一
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学籍番号 (推奨):
[継承]
4. (英) Kishihara Kenji (日) (読)
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5.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Lunatic fringe controls T cell differentiation through modulating Notch signaling.  (日)    [継承]
副題 (任意):
要約 (任意): (英) T cells differentiate from bone marrow-derived stem cells by expressing developmental stage-specific genes. We here searched arrays of genes that are highly expressed in mature CD4-CD8+ (CD8 single-positive (SP)) T cells but little in CD4+CD8+ (double-positive (DP)) cells by cDNA subtraction. Lunatic fringe (Lfng), a modulator of Notch signaling, was identified to be little expressed in DP cells and highly expressed in CD8SP T cell as well as in CD4-CD8- (double-negative (DN)) and mature CD4+CD8- (CD4SP) T cells. Thus, we examined whether such change of expression of Lfng plays a role in T cell development. We found that overexpression of Lfng in Jurkat T cells strengthened Notch signaling by reporter gene assay, indicating that Lfng is a positive regulator for Notch signaling in T cells. The enforced expression of Lfng in thymocytes enhanced the development of immature CD8SP cells but decreased mature CD4SP and CD8SP cells. In contrast, the down-regulation of Lfng in thymocytes suppressed DP cells development due to the defective transition from CD44+CD25- stage to subsequent stage in DN cells. The overexpression of Lfng in fetal liver-derived hemopoietic stem cells enhanced T cell development, whereas its down-regulation suppressed it. These results suggested that the physiological high expression of Lfng in DN cells contributes to enhance T cell differentiation through strengthening Notch signaling. Shutting down the expression of Lfng in DP cells may have a physiological role in promoting DP cells differentiation toward mature SP cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD4 (日) (読) [継承]
3. (英) Antigens, CD8 (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5. (英) Gene Expression Regulation (日) (読) [継承]
6. (英) Glycosyltransferases (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Jurkat Cells (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Receptors, Notch (日) (読) [継承]
12.シグナル伝達 (signal transduction) [継承]
13.Tリンパ球 (T lymphocytes) [継承]
14. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 177 [継承]
(必須): 12 [継承]
(必須): 8365 8371 [継承]
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年月日 (必須): 西暦 2006年 12月 15日 (平成 18年 12月 15日) [継承]
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PMID (任意): 17142733    (→Scopusで検索) [継承]
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WOS (任意): 000243416800012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichi Tsukumo, Kayo Hirose, Yoichi Maekawa, Kenji Kishihara and Koji Yasutomo : Lunatic fringe controls T cell differentiation through modulating Notch signaling., The Journal of Immunology, Vol.177, No.12, 8365-8371, 2006.
欧文冊子 ● Shin-ichi Tsukumo, Kayo Hirose, Yoichi Maekawa, Kenji Kishihara and Koji Yasutomo : Lunatic fringe controls T cell differentiation through modulating Notch signaling., The Journal of Immunology, Vol.177, No.12, 8365-8371, 2006.

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