『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.器官病態修復医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.銭 志栄
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2.佐野 壽昭
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3.吉本 勝彦
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4. (英) Sylvia L Asa (日) (読)
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5. (英) Yamada Shozo (日) (読)
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6.水澤 典子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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7.工藤 英治
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題名 (必須): (英) Tumor-specific down-regulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas  (日)    [継承]
副題 (任意):
要約 (任意): (英) The gene products of CDH13 and CDH1, H-cadherin and E-cadherin, respectively, play a key role in cell-cell adhesion. Inactivation of the cadherin-mediated cell adhesion system caused by aberrant methylation is a common finding in human cancers, indicating that the CDH13 and CDH1 function as tumor suppressor and invasion suppressor genes. In this study, we analyzed the expression of H-cadherin mRNA and E-cadherin protein in 5 normal pituitary tissues and 69 primary pituitary adenomas including all major types by quantitative real-time RT-PCR (qRT-PCR) and immunohistochemistry, respectively. Reduced expression of H-cadherin was detected in 54% (28/52) of pituitary tumors and was significantly associated with tumor aggressiveness (P<0.05). E-cadherin expression was lost in 30% (21 of 69) and significantly reduced in 32% (22 of 69) of tumors. E-cadherin expression was significantly lower in grade II, III, and IV than in grade I adenomas (P=0.015, P=0.029, and P=0.01, respectively). Using methylation-specific PCR (MSP), promoter hypermethylation of CDH13 and CDH1 was detected in 30 and 36% of 69 adenomas, respectively, but not in 5 normal pituitary tissues. Methylation of CDH13 was observed more frequently in invasive adenomas (42%) than in non-invasive adenomas (19%) (P<0.05) and methylation of CDH1 was more frequent in grade IV adenomas compared with grade I adenomas (P<0.05). Methylation of either CDH13 or CDH1 was identified in 35 cases (51%) and was more frequent in grade IV invasive adenomas than in grade I non-invasive adenomas (P<0.05 and P<0.05, respectively). Downregulation of expression was correlated with promoter hypermethylation in CDH13 and CDH1. In conclusion, the tumor-specific downregulation of expression and methylation of CDH13 and CDH1, alone or in combination, may be involved in the development and invasive growth of pituitary adenomas.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoma (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Cadherins (日) (読) [継承]
4. (英) DNA Methylation (日) (読) [継承]
5. (英) Down-Regulation (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Expression (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Pituitary Neoplasms (日) (読) [継承]
13. (英) Promoter Regions, Genetic (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Tumor Markers, Biological (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Modern Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)

ISSN (任意): 0893-3952
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Nature
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年月日 (必須): 西暦 2007年 9月 14日 (平成 19年 9月 14日) [継承]
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DOI (任意): 10.1038/modpathol.3800965    (→Scopusで検索) [継承]
PMID (任意): 17873891    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan. zrqian@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Zhi-Rong Qian, Toshiaki Sano, Katsuhiko Yoshimoto, Asa L Sylvia, Shozo Yamada, Noriko Mizusawa and Eiji Kudo : Tumor-specific down-regulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas, Modern Pathology, Vol.20, No.12, 1269-1277, 2007.
欧文冊子 ● Zhi-Rong Qian, Toshiaki Sano, Katsuhiko Yoshimoto, Asa L Sylvia, Shozo Yamada, Noriko Mizusawa and Eiji Kudo : Tumor-specific down-regulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas, Modern Pathology, Vol.20, No.12, 1269-1277, 2007.

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