『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162274EID:162274, Map:0, LastModified:2012年10月29日(月) 13:45:50, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.The Forsyth Institute, Department of Immunology [継承]
2.徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.健康長寿歯科学講座 (2004年4月1日〜) [継承]
3.広島大学.歯学部附属病院 [継承]
4.三菱ウェルファーマ 株式会社 [継承]
著者 (必須): 1.河井 敬久 ([The Forsyth Institute, Department of Immunology])
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学籍番号 (推奨):
[継承]
2. (英) Matsuyama Takashi (日) (読)
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[継承]
3.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
4.牧平 清超 ([広島大学.歯学部附属病院])
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[継承]
5.関 誠 ([三菱ウェルファーマ 株式会社])
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[継承]
6. (英) Nadeem Karimbux (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Reginaldo B. Goncalves (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Paloma Valverde (日) (読)
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[継承]
9. (英) Serge Dibart (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Yi-Ping Li (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Leticia A. Miranda (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Cory W.O. Ernst (日) (読)
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学籍番号 (推奨):
[継承]
13. (英) Yuichi Izumi (日) (読)
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[継承]
14.Taubman Martin ([The Forsyth Institute, Department of Immunology])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease  (日)    [継承]
副題 (任意):
要約 (任意): (英) Receptor activator of nuclear factor-kappaB (RANKL)-mediated osteoclastogenesis plays a pivotal role in inflammatory bone resorption. The aim of this study was to identify the cellular source of RANKL in the bone resorptive lesions of periodontal disease. The concentrations of soluble RANKL, but not its decoy receptor osteoprotegerin, measured in diseased tissue homogenates were significantly higher in diseased gingival tissues than in healthy tissues. Double-color confocal microscopic analyses demonstrated less than 20% of both B cells and T cells expressing RANKL in healthy gingival tissues. By contrast, in the abundant mononuclear cells composed of 45% T cells, 50% B cells, and 5% monocytes in diseased gingival tissues, more than 50 and 90% of T cells and B cells, respectively, expressed RANKL. RANKL production by nonlymphoid cells was not distinctly identified. Lymphocytes isolated from gingival tissues of patients induced differentiation of mature osteoclast cells in a RANKL-dependent manner in vitro. However, similarly isolated peripheral blood B and T cells did not induce osteoclast differentiation, unless they were activated in vitro to express RANKL; emphasizing the osteoclastogenic potential of activated RANKL-expressing lymphocytes in periodontal disease tissue. These results suggest that activated T and B cells can be the cellular source of RANKL for bone resorption in periodontal diseased gingival tissue.  (日)    [継承]
キーワード (推奨): 1. (英) B-Lymphocytes (日) (読) [継承]
2. (英) Bone Resorption (日) (読) [継承]
3. (英) Carrier Proteins (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Gingiva (日) (読) [継承]
8. (英) Glycoproteins (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Lymphocyte Activation (日) (読) [継承]
11. (英) Membrane Glycoproteins (日) (読) [継承]
12. (英) Microscopy, Confocal (日) (読) [継承]
13. (英) Osteoclasts (日) (読) [継承]
14. (英) Osteoprotegerin (日) (読) [継承]
15. (英) Periodontitis (日) (読) [継承]
16. (英) RANK Ligand (日) (読) [継承]
17. (英) Receptor Activator of Nuclear Factor-kappa B (日) (読) [継承]
18. (英) Receptors, Cytoplasmic and Nuclear (日) (読) [継承]
19. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
20. (英) T-Lymphocytes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)

ISSN (任意): 0002-9440
ISSN: 0002-9440 (pISSN: 0002-9440, eISSN: 1525-2191)
Title: The American journal of pathology
Title(ISO): Am J Pathol
Publisher: American Society for Investigative Pathology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意):
年月日 (必須): 西暦 2006年 9月 初日 (平成 18年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.2353/ajpath.2006.060180    (→Scopusで検索) [継承]
PMID (任意): 16936272    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) OtherID: PMC1698808  (日)    [継承]

標準的な表示

和文冊子 ● Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seichou Makihira, Makoto Seki, Karimbux Nadeem, Goncalves B. Reginaldo, Valverde Paloma, Dibart Serge, Li Yi-Ping, Miranda A. Leticia, Ernst W.O. Cory, Izumi Yuichi and Martin A Taubman : B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease, The American Journal of Pathology, Vol.169, No.3, 987-998, 2006.
欧文冊子 ● Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seichou Makihira, Makoto Seki, Karimbux Nadeem, Goncalves B. Reginaldo, Valverde Paloma, Dibart Serge, Li Yi-Ping, Miranda A. Leticia, Ernst W.O. Cory, Izumi Yuichi and Martin A Taubman : B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease, The American Journal of Pathology, Vol.169, No.3, 987-998, 2006.

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