『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162259EID:162259, Map:0, LastModified:2013年7月19日(金) 18:41:54, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.健康長寿歯科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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[継承]
3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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[継承]
4.中江 英明
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[継承]
5.松尾 敬志
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学籍番号 (推奨):
[継承]
題名 (必須): (英) CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Periodontal disease is an inflammatory disorder characterized by the involvement of chemokines that are important for the recruitment of leucocytes. Several cytokines are involved in regulating levels of chemokines in periodontal disease. CXCL16 is a chemokine related to the migration of T helper 1 (Th1) cells and natural killer (NK) cells. In this study, we examined its expression in periodontal tissues. Moreover, we investigated the effects of cytokines on the production of CXCL16 by human gingival fibroblast (HGF). Reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry revealed that CXCL16 and its receptor, CXCR6, were expressed at the mRNA and protein levels in diseased tissues. Proinflammatory cytokines [interleukin (IL)-1beta, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma] increased the mRNA expression and release of CXCL16 in a dose-dependent manner. Moreover, treatment of HGFs with IFN-gamma in combination with IL-1beta had a synergistic effect on the production of CXCL16. On the other hand, IL-4 and IL-13 inhibited the IL-1beta-induced CXCL16 production by HGFs. Inhibitors of A disintegrin and metalloprotease (ADAM)10 and ADAM17, a recently identified protease of CXCL16, reduced the amount of CXCL16 released from HGFs. These results suggest that the CXCL16 produced by HGFs may be involved in the migration of leucocytes into inflamed tissues, and provide evidence that CXCL16 production is controlled by cytokines in periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Chemokines, CXC (日) (読) [継承]
4. (英) Chronic Disease (日) (読) [継承]
5. (英) Cytokines (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Fibroblasts (日) (読) [継承]
8. (英) Gene Expression (日) (読) [継承]
9. (英) Gingiva (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Interferon-gamma (日) (読) [継承]
12. (英) Interleukin-13 (日) (読) [継承]
13. (英) Interleukin-1beta (日) (読) [継承]
14. (英) Interleukin-4 (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Metalloproteases (日) (読) [継承]
17. (英) Middle Aged (日) (読) [継承]
18. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
19. (英) Periodontitis (日) (読) [継承]
20. (英) RNA, Messenger (日) (読) [継承]
21. (英) Receptors, Chemokine (日) (読) [継承]
22. (英) Receptors, Scavenger (日) (読) [継承]
23. (英) Receptors, Virus (日) (読) [継承]
24. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 149 [継承]
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年月日 (必須): 西暦 2007年 7月 初日 (平成 19年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2007.03398.x    (→Scopusで検索) [継承]
PMID (任意): 17459077    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1942022  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts., Clinical and Experimental Immunology, Vol.149, No.1, 146-154, 2007.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts., Clinical and Experimental Immunology, Vol.149, No.1, 146-154, 2007.

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