『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162251EID:162251, Map:0, LastModified:2013年7月19日(金) 18:42:25, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.健康長寿歯科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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学籍番号 (推奨):
[継承]
3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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学籍番号 (推奨):
[継承]
4.中江 英明
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学籍番号 (推奨):
[継承]
5.松尾 敬志
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multi-functional cytokine that regulates cellular proliferation, angiogenesis, inflammation and apoptosis. In this study, we investigated TWEAK expression in periodontally diseased tissues and the effect of TWEAK on human gingival fibroblasts (HGF). Reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry revealed that TWEAK and the TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), mRNA and protein were expressed in periodontally diseased tissues. HGF expressed Fn14 and produced interleukin (IL)-8 and vascular endothelial growth factor (VEGF) production upon TWEAK stimulation in a dose-dependent manner. The IL-8 and VEGF production induced by TWEAK was augmented synergistically by simultaneous stimulation with transforming growth factor (TGF)-beta1 or IL-1beta. IL-1beta and TGF-beta1 enhanced Fn14 expression in a dose-dependent manner. Moreover, TWEAK induced intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expression on HGF in a dose-dependent manner. The ICAM-1 expression induced by TWEAK was augmented by TGF-beta1. On the other hand, the TWEAK-induced VCAM-1 expression was inhibited by TGF-beta1. Phosphatidylinositol 3-kinase (PI3K) and nuclear factor-kappaB (NF-kappaB) inhibitor inhibit both ICAM-1 and VCAM-1 expression induced by TWEAK. However, mitogen-activated protein kinase (MEK) and c-Jun NH2-terminal kinase (JNK) inhibitor enhanced only VCAM-1 expression on HGF. These results suggest that TWEAK may be involved in the pathophysiology of periodontal disease. Moreover, in combination with IL-1beta or TGF-beta1, TWEAK may be related to the exacerbation of periodontal disease to induce proinflammatory cytokines and adherent molecules by HGF.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Apoptosis (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Dose-Response Relationship, Immunologic (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Fibroblasts (日) (読) [継承]
9. (英) Gene Expression (日) (読) [継承]
10. (英) Gingiva (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
13. (英) Interleukin-1beta (日) (読) [継承]
14. (英) Interleukin-8 (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Middle Aged (日) (読) [継承]
17. (英) Periodontitis (日) (読) [継承]
18. (英) RNA, Messenger (日) (読) [継承]
19. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
20. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
21. (英) Signal Transduction (日) (読) [継承]
22. (英) Transforming Growth Factor beta1 (日) (読) [継承]
23. (英) Tumor Necrosis Factors (日) (読) [継承]
24. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
25. (英) Vascular Endothelial Growth Factor A (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 146 [継承]
(必須): 3 [継承]
(必須): 540 549 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 12月 初日 (平成 18年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2006.03233.x    (→Scopusで検索) [継承]
PMID (任意): 17100776    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1810398  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts., Clinical and Experimental Immunology, Vol.146, No.3, 540-549, 2006.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts., Clinical and Experimental Immunology, Vol.146, No.3, 540-549, 2006.

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