『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162228EID:162228, Map:0, LastModified:2013年7月19日(金) 18:43:34, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.健康長寿歯科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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[継承]
3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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[継承]
4.中江 英明
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[継承]
5.松尾 敬志
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The expression of intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) on human gingival fibroblasts (HGF) may be important for migration and retention of inflammatory cells in periodontally diseased tissue. This study aimed to assess which cytokines regulate ICAM-1 and VCAM-1 expression on HGF. Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma enhanced both ICAM-1 and VCAM-1 expression on HGF. Interleukin (IL)-1beta mainly up-regulated ICAM-1 expression. On the other hand, IL-4 and IL-13 enhanced only VCAM-1 expression on HGF. IL-10 did not modulate both ICAM-1 and VCAM-1 expression. Transforming growth factor (TGF)-beta1 enhanced ICAM-1 expression. However, TGF-beta1 inhibited the VCAM-1 expression induced by TNF-alpha or IL-4. Both ICAM-1 and VCAM-1 expression by HGF was inhibited by nuclear factor-kappaB (NF-kappaB) activation inhibitor (MG-132). Mitogen-activated protein kinases (MAPK) inhibitors did not influence ICAM-1 expression induced by TNF-alpha. Interestingly, VCAM-1 expression was enhanced by MEK inhibitor (PD98059) and c-Jun NH2-terminal kinase (JNK) inhibitor (SP600125). These results mean that the balance of cytokines in periodontally diseased tissue may be essential for control of ICAM-1 and VCAM-1 expression on HGF, and the balance of ICAM-1 and VCAM-1 expression might be important for regulation of leucocytes infiltration and retention in periodontally diseased tissue.  (日)    [継承]
キーワード (推奨): 1. (英) Cells, Cultured (日) (読) [継承]
2. (英) Cytokines (日) (読) [継承]
3. (英) Drug Synergism (日) (読) [継承]
4. (英) Enzyme Inhibitors (日) (読) [継承]
5. (英) Fibroblasts (日) (読) [継承]
6. (英) Flow Cytometry (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Gingiva (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Imidazoles (日) (読) [継承]
11. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
12. (英) Leupeptins (日) (読) [継承]
13. (英) Mitogen-Activated Protein Kinase Kinases (日) (読) [継承]
14. (英) NF-kappa B (日) (読) [継承]
15. (英) Pyridines (日) (読) [継承]
16. (英) RNA, Messenger (日) (読) [継承]
17. (英) Recombinant Proteins (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 144 [継承]
(必須): 3 [継承]
(必須): 494 502 [継承]
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年月日 (必須): 西暦 2006年 6月 初日 (平成 18年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2006.03064.x    (→Scopusで検索) [継承]
PMID (任意): 16734619    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1941975  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts., Clinical and Experimental Immunology, Vol.144, No.3, 494-502, 2006.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts., Clinical and Experimental Immunology, Vol.144, No.3, 494-502, 2006.

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