| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fujii Takafumi (日) (読)
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| 2. | (英) Nagaya Noritoshi (日) (読)
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| 3. | 岩瀬 俊
| ○役割 (任意): | □ | 共著
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| 4. | (英) Murakami Shinsuke (日) (読)
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| 5. | (英) Miyahara Yoshinori (日) (読)
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| 6. | (英) Nishigami Kazuhiro (日) (読)
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| 7. | (英) Ishibashi-Ueda Hatsue (日) (読)
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| 8. | (英) Shirai Mikiyasu (日) (読)
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| 9. | (英) Itoh Takefumi (日) (読)
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| 10. | (英) Ishino Kozo (日) (読)
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| 11. | (英) Sano Shunji (日) (読)
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| ○貢献度 (任意): |
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| 12. | 寒川 賢治 (国立循環器病センター研究所)
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| ○学籍番号 (推奨): |
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| 13. | (英) Mori Hidezo (日) (読)
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| ○題名 (必須): | □ | (英) Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Adrenomedullin (AM), a potent vasodilator, induces angiogenesis and inhibits cell apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. Transplantation of bone marrow-derived mononuclear cells (MNC) induces angiogenesis. We investigated whether infusion of AM enhances the therapeutic potency of MNC transplantation in a rat model of myocardial infarction. Immediately after coronary ligation, bone marrow-derived MNC (5 x 10(6) cells) were injected into the ischemic myocardium, followed by subcutaneous administration of 0.05 microg x kg(-1) x min(-1) AM (AM-MNC group) or saline (MNC group) for 3 days. Another two groups of rats received subcutaneous administration of AM alone (AM group) or saline (control group). Hemodynamic and histological analyses were performed 4 wk after treatment. Cardiac infarct size was significantly smaller in the MNC and AM groups than in the control group. A combination of AM infusion and MNC transplantation demonstrated a further decrease in infarct size. Left ventricular (LV) maximum change in pressure over time and LV fractional shortening were significantly improved only in the AM-MNC group. AM significantly increased capillary density in ischemic myocardium, suggesting the angiogenic potency of AM. AM infusion plus MNC transplantation demonstrated a further increase in capillary density compared with AM or MNC alone. Although MNC apoptosis was frequently observed 72 h after transplantation, AM markedly decreased the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive cells among the transplanted MNC. In conclusion, AM enhanced the angiogenic potency of MNC transplantation and improved cardiac function in rats with myocardial infarction. This beneficial effect may be mediated partly by the angiogenic property of AM itself and by its antiapoptotic effect on MNC. (日)
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| ○キーワード (推奨): | 1. | (英) Adrenomedullin (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | アポトーシス (apoptosis)
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| 4. | (英) Bone Marrow Transplantation (日) (読)
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| 5. | (英) Capillaries (日) (読)
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| 6. | 細胞分化 (cell differentiation)
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| 7. | (英) Combined Modality Therapy (日) (読)
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| 8. | (英) Coronary Circulation (日) (読)
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| 9. | (英) Echocardiography (日) (読)
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| 10. | (英) Endothelium, Vascular (日) (読)
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| 11. | (英) Graft Survival (日) (読)
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| 12. | (英) Heart Ventricles (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Myocardial Infarction (日) (読)
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| 15. | 心筋 (myocardium)
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| 16. | (英) Neovascularization, Physiologic (日) (読)
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| 17. | (英) Organ Size (日) (読)
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| 18. | (英) Peptides (日) (読)
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| 19. | (英) Rats (日) (読)
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| 20. | (英) Rats, Inbred Lew (日) (読)
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| 21. | (英) Vasodilator Agents (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)
| ○ISSN (任意): | □ | 0363-6135
ISSN: 0363-6135
(pISSN: 0363-6135, eISSN: 1522-1539) Title: American journal of physiology. Heart and circulatory physiologyTitle(ISO): Am J Physiol Heart Circ PhysiolPublisher: American Physiological Society (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 288
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | H1444 H1450
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 3月 初日 (平成 17年 3月 初日)
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| ○URL (任意): | □ | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15539427
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| ○DOI (任意): | □ | 10.1152/ajpheart.00266.2004 (→Scopusで検索)
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| ○PMID (任意): | □ | 15539427 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000226911100061
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| ○Scopus (任意): | □ | 2-s2.0-13944279184
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Cardiac Physiology, National Cardiovascular Center, Suita, Osaka, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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