『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nagaya Noritoshi (日) (読)
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[継承]
2. (英) Fujii Takafumi (日) (読)
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[継承]
3.岩瀬 俊
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[継承]
4. (英) Ohgushi Hajime (日) (読)
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[継承]
5. (英) Itoh Takefumi (日) (読)
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[継承]
6. (英) Uematsu Masaaki (日) (読)
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[継承]
7. (英) Yamagishi Masakazu (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Mori Hidezo (日) (読)
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9.寒川 賢治 (国立循環器病センター研究所)
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[継承]
10. (英) Kitamura Soichiro (日) (読)
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[継承]
題名 (必須): (英) Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mesenchymal stem cells (MSCs) are pluripotent cells that differentiate into a variety of cells, including cardiomyocytes and endothelial cells. However, little information is available regarding the therapeutic potency of systemically delivered MSCs for myocardial infarction. Accordingly, we investigated whether intravenously transplanted MSCs induce angiogenesis and myogenesis and improve cardiac function in rats with acute myocardial infarction. MSCs were isolated from bone marrow aspirates of isogenic adult rats and expanded ex vivo. At 3 h after coronary ligation, 5 x 10(6) MSCs (MSC group, n=12) or vehicle (control group, n=12) was intravenously administered to Lewis rats. Transplanted MSCs were preferentially attracted to the infarcted, but not the noninfarcted, myocardium. The engrafted MSCs were positive for cardiac markers: desmin, cardiac troponin T, and connexin43. On the other hand, some of the transplanted MSCs were positive for von Willebrand factor and formed vascular structures. Capillary density was markedly increased after MSC transplantation. Cardiac infarct size was significantly smaller in the MSC than in the control group (24 +/- 2 vs. 33 +/- 2%, P <0.05). MSC transplantation decreased left ventricular end-diastolic pressure and increased left ventricular maximum dP/dt (both P <0.05 vs. control). These results suggest that intravenous administration of MSCs improves cardiac function after acute myocardial infarction through enhancement of angiogenesis and myogenesis in the ischemic myocardium.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.細胞分化 (cell differentiation) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Diastole (日) (読) [継承]
5. (英) Injections, Intravenous (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Mesoderm (日) (読) [継承]
8. (英) Myocardial Infarction (日) (読) [継承]
9. (英) Myocytes, Cardiac (日) (読) [継承]
10. (英) Neovascularization, Physiologic (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Inbred Lew (日) (読) [継承]
13. (英) Stem Cell Transplantation (日) (読) [継承]
14. (英) Ventricular Pressure (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)

ISSN (任意): 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am J Physiol Heart Circ Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 287 [継承]
(必須): 6 [継承]
(必須): H2670 H2676 [継承]
都市 (任意):
年月日 (必須): 西暦 2004年 12月 初日 (平成 16年 12月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15284059 [継承]
DOI (任意): 10.1152/ajpheart.01071.2003    (→Scopusで検索) [継承]
PMID (任意): 15284059    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000225165700038 [継承]
Scopus (任意): 2-s2.0-9344265225 [継承]
評価値 (任意):
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備考 (任意): 1.(英) Article.Affiliation: Dept. of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. nnagaya@ri.ncvc.go.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Noritoshi Nagaya, Takafumi Fujii, Takashi Iwase, Hajime Ohgushi, Takefumi Itoh, Masaaki Uematsu, Masakazu Yamagishi, Hidezo Mori, Kenji Kangawa and Soichiro Kitamura : Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis, American Journal of Physiology, Heart and Circulatory Physiology, Vol.287, No.6, H2670-H2676, 2004.
欧文冊子 ● Noritoshi Nagaya, Takafumi Fujii, Takashi Iwase, Hajime Ohgushi, Takefumi Itoh, Masaaki Uematsu, Masakazu Yamagishi, Hidezo Mori, Kenji Kangawa and Soichiro Kitamura : Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis, American Journal of Physiology, Heart and Circulatory Physiology, Vol.287, No.6, H2670-H2676, 2004.

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