『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Murakami Shinsuke (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Nagaya Noritoshi (日) (読)
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[継承]
3. (英) Itoh Takefumi (日) (読)
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[継承]
4. (英) Fujii Takafumi (日) (読)
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[継承]
5.岩瀬 俊
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[継承]
6. (英) Hamada Kaoru (日) (読)
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[継承]
7. (英) Kimura Hiroshi (日) (読)
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[継承]
8.寒川 賢治 (国立循環器病センター研究所)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) C-type natriuretic peptide (CNP) has been shown to play an important role in the regulation of vascular tone and remodeling. However, the physiological role of CNP in the lung remains unknown. Accordingly, we investigated whether CNP infusion attenuates bleomycin (BLM)-induced pulmonary fibrosis in mice. After intratracheal injection of BLM or saline, mice were randomized to receive continuous infusion of CNP or vehicle for 14 days. CNP infusion significantly reduced the total number of cells and the numbers of macrophages, neutrophils, and lymphocytes in bronchoalveolar lavage fluid. Interestingly, CNP markedly reduced bronchoalveolar lavage fluid IL-1beta levels. Immunohistochemical analysis demonstrated that CNP significantly inhibited infiltration of macrophages into the alveolar and interstitial regions. CNP infusion significantly attenuated BLM-induced pulmonary fibrosis, as indicated by significant decreases in Ashcroft score and lung hydroxyproline content. CNP markedly decreased the number of Ki-67-positive cells in fibrotic lesions of the lung, suggesting antiproliferative effects of CNP on pulmonary fibrosis. Kaplan-Meier survival curves demonstrated that BLM mice treated with CNP had a significantly higher survival rate than those given vehicle. These results suggest that continuous infusion of CNP attenuates BLM-induced pulmonary fibrosis and improves survival in BLM mice, at least in part by inhibition of pulmonary inflammation and cell proliferation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bleomycin (日) (読) [継承]
3. (英) Bronchoalveolar Lavage Fluid (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Hydroxyproline (日) (読) [継承]
6. (英) Infusions, Parenteral (日) (読) [継承]
7. (英) Interleukin-1 (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Natriuretic Peptide, C-Type (日) (読) [継承]
11.肺線維症 (pulmonary fibrosis) [継承]
12. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology. Lung Cellular and Molecular Physiology ([アメリカ生理学会])
(pISSN: 1040-0605, eISSN: 1522-1504)

ISSN (任意): 1040-0605
ISSN: 1040-0605 (pISSN: 1040-0605, eISSN: 1522-1504)
Title: American journal of physiology. Lung cellular and molecular physiology
Title(ISO): Am J Physiol Lung Cell Mol Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 287 [継承]
(必須): 6 [継承]
(必須): L1172 L1177 [継承]
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年月日 (必須): 西暦 2004年 12月 初日 (平成 16年 12月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15285999 [継承]
DOI (任意): 10.1152/ajplung.00087.2004    (→Scopusで検索) [継承]
PMID (任意): 15285999    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000224956900014 [継承]
Scopus (任意): 2-s2.0-8644232666 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine, National Cardiovascular Center, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Takafumi Fujii, Takashi Iwase, Kaoru Hamada, Hiroshi Kimura and Kenji Kangawa : C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice, American Journal of Physiology. Lung Cellular and Molecular Physiology, Vol.287, No.6, L1172-L1177, 2004.
欧文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Takafumi Fujii, Takashi Iwase, Kaoru Hamada, Hiroshi Kimura and Kenji Kangawa : C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice, American Journal of Physiology. Lung Cellular and Molecular Physiology, Vol.287, No.6, L1172-L1177, 2004.

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