『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.病院.先端医療開発研究プロジェクト [継承]
著者 (必須): 1. (英) Itoh Takefumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nagaya Noritoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Fujii Takafumi (日) (読)
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[継承]
4.岩瀬 俊
役割 (任意): 共著 [継承]
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学籍番号 (推奨):
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5. (英) Nakanishi Norifumi (日) (読)
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[継承]
6. (英) Hamada Kaoru (日) (読)
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[継承]
7.寒川 賢治 (国立循環器病センター研究所)
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学籍番号 (推奨):
[継承]
8. (英) Kimura Hiroshi (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Sildenafil, an oral phosphodiesterase type-5 inhibitor, has vasodilatory effects through a cyclic guanosine 3', 5'-monophosphate-dependent mechanism, whereas beraprost, an oral prostacyclin analog, induces vasorelaxation through a cAMP-dependent mechanism. We investigated whether the combination of oral sildenafil and beraprost is superior to each drug alone in the treatment of pulmonary hypertension. Rats were randomized to receive repeated administration of saline, sildenafil, beraprost, or both of these drugs twice a day for 3 weeks. Three weeks after monocrotaline (MCT) injection, there was significant development of pulmonary hypertension. The increases in right ventricular systolic pressure and ratio of right ventricular weight to body weight were significantly attenuated in the Sildenafil and Beraprost groups. Combination therapy with sildenafil and beraprost had additive effects on increases in plasma cAMP and cyclic guanosine 3', 5'-monophosphate levels, resulting in further improvement in pulmonary hemodynamics compared with treatment with each drug alone. Unlike MCT rats given saline, sildenafil, or beraprost alone, all rats treated with both drugs remained alive during 6-week follow-up. These results suggest that combination therapy with oral sildenafil and beraprost attenuates the development of MCT-induced pulmonary hypertension compared with treatment with each drug alone.  (日)    [継承]
キーワード (推奨): 1. (英) Administration, Oral (日) (読) [継承]
2.分散分析 (analysis of variance) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cyclic GMP (日) (読) [継承]
5. (英) Disease Models, Animal (日) (読) [継承]
6. (英) Dose-Response Relationship, Drug (日) (読) [継承]
7. (英) Drug Administration Schedule (日) (読) [継承]
8. (英) Drug Therapy, Combination (日) (読) [継承]
9. (英) Epoprostenol (日) (読) [継承]
10. (英) Hemodynamics (日) (読) [継承]
11. (英) Hypertension, Pulmonary (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Piperazines (日) (読) [継承]
14.確率 (probability) [継承]
15. (英) Purines (日) (読) [継承]
16. (英) Random Allocation (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Wistar (日) (読) [継承]
19. (英) Sulfones (日) (読) [継承]
20. (英) Survival Rate (日) (読) [継承]
21. (英) Vascular Patency (日) (読) [継承]
22. (英) Vasodilator Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
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年月日 (必須): 西暦 2004年 1月 初日 (平成 16年 1月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14525801 [継承]
DOI (任意): 10.1164/rccm.200303-346OC    (→Scopusで検索) [継承]
PMID (任意): 14525801    (→Scopusで検索) [継承]
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WOS (任意): 000187570500011 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takefumi Itoh, Noritoshi Nagaya, Takafumi Fujii, Takashi Iwase, Norifumi Nakanishi, Kaoru Hamada, Kenji Kangawa and Hiroshi Kimura : A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats, American Journal of Respiratory and Critical Care Medicine, Vol.169, No.1, 34-38, 2004.
欧文冊子 ● Takefumi Itoh, Noritoshi Nagaya, Takafumi Fujii, Takashi Iwase, Norifumi Nakanishi, Kaoru Hamada, Kenji Kangawa and Hiroshi Kimura : A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats, American Journal of Respiratory and Critical Care Medicine, Vol.169, No.1, 34-38, 2004.

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