『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Itoh Takefumi (日) (読)
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[継承]
2. (英) Nagaya Noritoshi (日) (読)
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3. (英) Murakami Shinsuke (日) (読)
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[継承]
4. (英) Fujii Takafumi (日) (読)
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[継承]
5.岩瀬 俊
役割 (任意): 共著 [継承]
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6. (英) Hatsue Ishibashi-Ueda (日) (読)
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7. (英) Chikao Yutani (日) (読)
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8. (英) Masakazu Yamagishi (日) (読)
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9. (英) Hiroshi Kimura (日) (読)
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10.寒川 賢治 (国立循環器病センター研究所)
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題名 (必須): (英) C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) C-type natriuretic peptide (CNP) has been shown to act as a local regulator of vascular tone and remodeling. We investigated whether CNP ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. Rats received a continuous infusion of CNP or placebo. Significant pulmonary hypertension developed 3 weeks after MCT. However, infusion of CNP significantly attenuated the development of pulmonary hypertension and vascular remodeling. Neither systemic arterial pressure nor heart rate was altered. Interestingly, CNP enhanced Ki-67 expression, a marker for cell proliferation, in pulmonary endothelial cells and augmented lung tissue content of endothelial nitric oxide synthase. CNP significantly suppressed apoptosis of pulmonary endothelial cells, decreased the number of monocytes/macrophages, and inhibited expression of plasminogen activator inhibitor type 1, a marker for fibrinolysis impairment, in the lung. In addition, CNP significantly increased the survival rate in MCT rats. Finally, infusion of CNP after the establishment of pulmonary hypertension also had beneficial effects on hemodynamics and survival. In conclusion, infusion of CNP ameliorated MCT-induced pulmonary hypertension and improved survival. These beneficial effects may be mediated by regeneration of pulmonary endothelium, inhibition of endothelial cell apoptosis, and prevention of monocyte/macrophage infiltration and fibrinolysis impairment.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antihypertensive Agents (日) (読) [継承]
3.アポトーシス (apoptosis) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Chemotaxis, Leukocyte (日) (読) [継承]
6. (英) Fibrinolysis (日) (読) [継承]
7. (英) Hemodynamics (日) (読) [継承]
8. (英) Hypertension, Pulmonary (日) (読) [継承]
9. (英) Injections, Subcutaneous (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Models, Animal (日) (読) [継承]
12. (英) Monocrotaline (日) (読) [継承]
13. (英) Natriuretic Peptide, C-Type (日) (読) [継承]
14. (英) Pulmonary Artery (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Wistar (日) (読) [継承]
17. (英) Respiratory Mucosa (日) (読) [継承]
18. (英) Survival Analysis (日) (読) [継承]
19. (英) Toxins, Biological (日) (読) [継承]
20. (英) Treatment Outcome (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
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(必須): 1204 1211 [継承]
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年月日 (必須): 西暦 2004年 12月 初日 (平成 16年 12月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15333333 [継承]
DOI (任意): 10.1164/rccm.200404-455OC    (→Scopusで検索) [継承]
PMID (任意): 15333333    (→Scopusで検索) [継承]
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WOS (任意): 000225444900013 [継承]
Scopus (任意): 2-s2.0-9644280890 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Evaluation Studies  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takefumi Itoh, Noritoshi Nagaya, Shinsuke Murakami, Takafumi Fujii, Takashi Iwase, Ishibashi-Ueda Hatsue, Yutani Chikao, Yamagishi Masakazu, Kimura Hiroshi and Kenji Kangawa : C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats, American Journal of Respiratory and Critical Care Medicine, Vol.170, No.11, 1204-1211, 2004.
欧文冊子 ● Takefumi Itoh, Noritoshi Nagaya, Shinsuke Murakami, Takafumi Fujii, Takashi Iwase, Ishibashi-Ueda Hatsue, Yutani Chikao, Yamagishi Masakazu, Kimura Hiroshi and Kenji Kangawa : C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats, American Journal of Respiratory and Critical Care Medicine, Vol.170, No.11, 1204-1211, 2004.

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