『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Norifumi kawada (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Natsuo Ueda (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Y. Mizoguchi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) K. Kobayashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) T. Monna (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) S. Morisawa (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7.石村 和敬
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学籍番号 (推奨):
[継承]
8.鈴木 登志子 (->個人[山本 登志子])
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学籍番号 (推奨):
[継承]
9. (英) Shozo Yamamoto (日) (読)
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[継承]
題名 (必須): (英) Increased 5-lipoxygenase activity in massive hepatic cell necrosis in the rat correlates with neutrophil infiltration  (日)    [継承]
副題 (任意):
要約 (任意): (英) Rats were treated with heat-killed Propionibacterium acnes and subsequent injection of a small amount of lipopolysaccharide after 7 days. After 24 hr most of the rats died of massive liver cell necrosis. Nonparenchymal liver cells were isolated from this liver injury model and incubated with arachidonic acid. Reverse-phase high-pressure liquid chromatography detected the 5-lipoxygenase metabolites (leukotriene B4 and 5-hydroxy-arachidonic acid), whereas these compounds were produced in negligible amounts when the rats were treated with P. acnes only. Immunohistochemical studies with 5-lipoxygenase antiserum revealed that the injured livers contained a large number of positively stained round cells with segmented nuclei, which were rarely found in the livers treated with P. acnes only. These positively stained cells were histologically identified as neutrophils. The results suggested that the increased 5-lipoxygenase activity in the injured rat liver is attributable to the infiltrating neutrophils rather than to nonparenchymal hepatic cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arachidonate 5-Lipoxygenase (日) (読) [継承]
3. (英) Arachidonic Acid (日) (読) [継承]
4. (英) Hydroxyeicosatetraenoic Acids (日) (読) [継承]
5.免疫組織化学 (immunohistochemistry) [継承]
6. (英) Leukotriene B4 (日) (読) [継承]
7. (英) Lipopolysaccharides (日) (読) [継承]
8. (英) Liver (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Necrosis (日) (読) [継承]
11. (英) Neutrophils (日) (読) [継承]
12. (英) Propionibacterium acnes (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Inbred Strains (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Hepatology (American Association for the Study of Liver Diseases)
(pISSN: 0270-9139, eISSN: 1527-3350)

ISSN (任意): 0270-9139
ISSN: 0270-9139 (pISSN: 0270-9139, eISSN: 1527-3350)
Title: Hepatology (Baltimore, Md.)
Title(ISO): Hepatology
Supplier: American Association for the Study of Liver Diseases
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 16 [継承]
(必須): 2 [継承]
(必須): 462 468 [継承]
都市 (任意):
年月日 (必須): 西暦 1992年 8月 初日 (平成 4年 8月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 1322350    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0026776392 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● kawada Norifumi, Ueda Natsuo, Mizoguchi Y., Kobayashi K., Monna T., Morisawa S., Kazunori Ishimura, Toshiko Suzuki and Yamamoto Shozo : Increased 5-lipoxygenase activity in massive hepatic cell necrosis in the rat correlates with neutrophil infiltration, Hepatology, Vol.16, No.2, 462-468, 1992.
欧文冊子 ● kawada Norifumi, Ueda Natsuo, Mizoguchi Y., Kobayashi K., Monna T., Morisawa S., Kazunori Ishimura, Toshiko Suzuki and Yamamoto Shozo : Increased 5-lipoxygenase activity in massive hepatic cell necrosis in the rat correlates with neutrophil infiltration, Hepatology, Vol.16, No.2, 462-468, 1992.

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