『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.山本 登志子
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2. (英) Sugimoto Yukihiko (日) (読)
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[継承]
3. (英) Ichikawa Atsushi (日) (読)
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4.石村 和敬
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the prostaglandin F(2alpha )receptor (FP). Western blot exhibited the expression of FP protein in wild type mouse testis, and that of prostaglandin F synthase and cyclooxygenase-1 proteins in the both of wild type mouse and FP-deficient mouse testes. The expression of prostaglandin F synthase and cyclooxygenase-1 were detected intensely in Leydig cell-rich fraction, and that of FP was detected equally in Leydig cell-rich fraction and the other fraction. Immunohistochemistry for cyclooxygenase-1 and prostaglandin F synthase demonstrated their co-localization in mouse Leydig cells. Histochemistry for FP demonstrated the localization in Leydig cells and in spermatids of seminiferous tubules. Double histochemical staining confirmed the co-localization of cyclooxygenase-1, prostaglandin F synthase and FP in the Leydig cells. These findings indicate that prostaglandin F(2alpha) may have an effect on the functions of Leyding cells in an autocrine fashion. It implies that prostaglandin F synthase and FP are involved in the control of testosterone release from Leydig cells and in spermatogenesis via the local pathway and the hypothalamo-hypophysial-testis pathway, and affect the testicular function.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cyclooxygenase 1 (日) (読) [継承]
3. (英) Hydroxyprostaglandin Dehydrogenases (日) (読) [継承]
4.免疫組織化学 (immunohistochemistry) [継承]
5. (英) Leydig Cells (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Inbred C57BL (日) (読) [継承]
9.ノックアウトマウス (knockout mice) [継承]
10. (英) Receptors, Prostaglandin (日) (読) [継承]
11. (英) Testis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Histochemistry and Cell Biology (Society for Histochemistry)
(pISSN: 0948-6143, eISSN: 1432-119X)

ISSN (任意): 0948-6143
ISSN: 0948-6143 (pISSN: 0948-6143, eISSN: 1432-119X)
Title: Histochemistry and cell biology
Title(ISO): Histochem Cell Biol
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 128 [継承]
(必須): 4 [継承]
(必須): 317 322 [継承]
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年月日 (必須): 西暦 2007年 8月 3日 (平成 19年 8月 3日) [継承]
URL (任意):
DOI (任意): 10.1007/s00418-007-0316-4    (→Scopusで検索) [継承]
PMID (任意): 17674023    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000249523100004 [継承]
Scopus (任意): 2-s2.0-34548695460 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. toshiko@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshiko Suzuki-Yamamoto, Yukihiko Sugimoto, Atsushi Ichikawa and Kazunori Ishimura : Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells., Histochemistry and Cell Biology, Vol.128, No.4, 317-322, 2007.
欧文冊子 ● Toshiko Suzuki-Yamamoto, Yukihiko Sugimoto, Atsushi Ichikawa and Kazunori Ishimura : Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells., Histochemistry and Cell Biology, Vol.128, No.4, 317-322, 2007.

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