| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): | □ | 依頼
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.医学科.病態予防医学講座
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| ○著者 (必須): | 1. | 東 満美
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| 2. | 芳地 一
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| 3. | (英) Nishisako Hirotaka (日) (読) にしさこ ひろたか
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| 4. | 石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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| 5. | 土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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| 6. | (英) Teraoka Kazuhiko (日) (読)
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| 7. | 池原 敏孝 ([徳島文理大学])
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| 8. | 楠見 武徳
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| 9. | 水口 和生
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| ○題名 (必須): | □ | (英) Inhibitory action of novel arginine derivative on catecholamine secretion evoked by acetylcholine from cultured bovine adrenal chromaffin cells (日)
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| ○要約 (任意): | □ | (英) A novel product, 4-amino-5-guanidinopentanoic acid 15-[(4-aminobutyl)-3-aminopropylcarbamoyl] pentadecyl ester (Arg-HSA-Spm), was synthesized based on ptilomycalin A, which is one of the extracts from marine sponge. Arg-HSA-Spm contains arginine in its chemical structure. The pharmacological action of Arg-HSA-Spm on catecholamine secretion from cultured bovine adrenal chromaffin cells was examined. Arg-HSA-Spm inhibited catecholamine secretion stimulated by the physiological secretagog acetylcholine. This inhibitory action of Arg-HSA-Spm on catecholamine secretion induced by 10(-4) M acetylcholine was dose-dependent from 10(-8) M to 10(-5) M. In the presence of 3 x 10(-7) M Arg-HSA-Spm, the stimulation of catecholamine secretion observed by increasing acetylcholine up to 10(-3) M did not reach the maximal level observed without Arg-HSA-Spm. Arg-HSA-Spm at 10(-5) M suppressed both the increase in intracellular free Ca2+ level and the influx of 45Ca2+ induced by 10(-4) M acetylcholine. The Arg-HSA-Spm-induced suppression of intracellular free Ca2+ level, the influx of 45Ca2+ and catecholamine secretion were not observed in the presence of extracellular K+ at 56 mM. The results presented in this study suggested that Arg-HSA-Spm may inhibit the influx of extracellular Ca2+ into the cells, probably through its blocking action related to acetylcholine receptors, resulting in the inhibition of catecholamine secretion in adrenal chromaffin cells. (日)
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| ○キーワード (推奨): | 1. | (英) Acetylcholine (日) (読)
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| 2. | (英) Adrenal Medulla (日) (読)
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| 3. | (英) Alkaloids (日) (読)
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| 4. | (英) Animals (日) (読)
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| 5. | (英) Arginine (日) (読)
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| 6. | カルシウム (calcium)
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| 7. | (英) Calcium Radioisotopes (日) (読)
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| 8. | (英) Carbamates (日) (読)
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| 9. | (英) Catecholamines (日) (読)
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| 10. | (英) Cattle (日) (読)
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| 11. | (英) Cells, Cultured (日) (読)
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| 12. | (英) Chromaffin Cells (日) (読)
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| 13. | (英) Dose-Response Relationship, Drug (日) (読)
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| 14. | (英) Guanidines (日) (読)
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| 15. | (英) Spermidine (日) (読)
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| ○発行所 (推奨): | □ | Lippincott Williams & Wilkins
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| ○誌名 (必須): | □ | Journal of Cardiovascular Pharmacology ([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)
| ○ISSN (任意): | □ | 0160-2446
ISSN: 0160-2446
(pISSN: 0160-2446, eISSN: 1533-4023) Title: Journal of cardiovascular pharmacologyTitle(ISO): J Cardiovasc PharmacolPublisher: Lippincott Williams and Wilkins Ltd. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 42
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| ○号 (必須): | □ | Suppl. 1
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| ○頁 (必須): | □ | S15 S18
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 12月 初日 (平成 15年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/00005344-200312001-00005 (→Scopusで検索)
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| ○PMID (任意): | □ | 14871022 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000187044500005
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan. mamichan@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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