『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=15998)

EID=15998EID:15998, Map:0, LastModified:2017年5月19日(金) 15:43:18, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ono Koji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Suzuki Minoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kinashi Yuko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Takagaki Masao (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.堀 均
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Kasai Soko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意): (英)   (日) TPZの合成を担当.   [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) C3H / He mice bearing SCC VII tumors received 5-bromo-2'-deoxyuridine (BrdU) continuously for 5 days via implanted mini-osmotic pumps to label all proliferating (P) cells. The mice then received one of six different DNA-damaging agents with or without mild temperature hyperthermia (40 degrees C, 30 min, MTH). These agents were adriamycin (ADM), mitomycin C (MMC), cyclophosphamide (CPA), bleomycin (BLM), cisplatin (CDDP), and tirapazamine (TPZ). After the drug treatment, the tumor-bearing mice were irradiated with a series of doses of gamma-rays. Immediately after irradiation, the tumors were excised, minced and trypsinized. The tumor cell suspensions thus obtained were incubated with cytochalasin-B (a cytokinesis blocker), and the micronucleus (MN) frequency in cells without BrdU labeling ( = quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total (P + Q) tumor cells was determined from the tumors that had not been pretreated with BrdU. MTH significantly increased the MN frequency of total cells in tumors irradiated with gamma-rays combined with CPA, BLM, CDDP or TPZ, and that of Q cells in tumors irradiated with gamma-rays combined with BLM or TPZ. The sensitivity difference in the MN frequency between total and Q tumor cells was significantly decreased by the combination with TPZ. TPZ combined with radiotherapy and TPZ combined with thermo-radiotherapy at mild temperatures appear to be promising modalities for sensitizing tumor cells in vivo, including Q tumor cells.  (日) 本論文では,腫瘍移殖担癌マウスモデルにおいて,TPZは種々の化学療法剤に比べて,放射線との併用,あるいはマイルドハイパーサーミア及び放射線との併用により,Q細胞に対して優位に増感作用を示すことを明らかにした.以上により,このような癌治療法において,TPZを併用することは有効であることを示した.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
3. (英) Bleomycin (日) (読) [継承]
4. (英) Bromodeoxyuridine (日) (読) [継承]
5. (英) Carcinoma, Squamous Cell (日) (読) [継承]
6. (英) Cisplatin (日) (読) [継承]
7. (英) Combined Modality Therapy (日) (読) [継承]
8. (英) Cyclophosphamide (日) (読) [継承]
9. (英) Dose-Response Relationship, Radiation (日) (読) [継承]
10. (英) Doxorubicin (日) (読) [継承]
11. (英) Hyperthermia, Induced (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C3H (日) (読) [継承]
14. (英) Micronucleus Tests (日) (読) [継承]
15. (英) Mitomycin (日) (読) [継承]
16. (英) Radiation-Sensitizing Agents (日) (読) [継承]
17. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Japanese Journal of Cancer Research ([日本癌学会])
(pISSN: 0910-5050)

ISSN (任意): 0910-5050
ISSN: 0910-5050 (pISSN: 0910-5050, eISSN: 1876-4673)
Title: Japanese journal of cancer research : Gann
Title(ISO): Jpn. J. Cancer Res.
Supplier: 日本癌学会
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 91 [継承]
(必須): 5 [継承]
(必須): 566 572 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 5月 1日 (平成 12年 5月 1日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 10835503    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0034081410 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Hitoshi Hori, Soko Kasai, Hideko Nagasawa and Yoshihiro Uto : Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells, Japanese Journal of Cancer Research, Vol.91, No.5, 566-572, 2000.
欧文冊子 ● Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Hitoshi Hori, Soko Kasai, Hideko Nagasawa and Yoshihiro Uto : Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells, Japanese Journal of Cancer Research, Vol.91, No.5, 566-572, 2000.

関連情報

Number of session users = 0, LA = 0.89, Max(EID) = 361923, Max(EOID) = 968362.