『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2. (英) Ono Koji (日) (読)
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[継承]
3. (英) Suzuki Minoru (日) (読)
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[継承]
4. (英) Kinashi Yuko (日) (読)
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[継承]
5. (英) Takagaki Masao (日) (読)
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[継承]
6. (英) Kasai Soko (日) (読)
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[継承]
7.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意): (英)   (日) TPZの合成を担当   [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
9.堀 均
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mice bearing solid tumors received 10 intraperitoneal administrations of 5-bromo-2'-deoxyuridine (BrdU) to label the proliferating (P) tumor cells. Then, as a priming treatment, tirapazamine (TPZ) was intraperitoneally administered. Further, 0 through 48 h later, the tumor-bearing mice received TPZ again at various doses. The tumor cells were isolated and incubated with a cytokinesis blocker. The micronucleus (MN) frequencies in cells with and without BrdU labeling, which were regarded as P and quiescent (Q) cells at the priming treatment, respectively, were determined using immunofluorescence staining for BrdU. The MN frequency in the total (P + Q) tumor cells was determined from the tumors that were not pretreated with BrdU. In addition, P cell ratios in the tumors at the second treatment were determined using immunofluorescence staining for P cell nuclear antigen. In each cell fraction, the longer the interval between the two treatments, the higher was the sensitivity to TPZ, except 1 h after the priming treatment. More than 24 h later, total and P cells, especially P cells, showed significantly higher sensitivity to TPZ than in the case of a single TPZ treatment. The longer the period between the two TPZ treatments, the lower was the P cell ratio at the second treatment. These findings were thought to indicate that the use of TPZ in the treatment of solid tumors causes a shift from the P to the Q state in vivo.  (日) 本論文では,腫瘍移殖担癌マウスモデルにおいて,TPZの分割投与により,その感受性を増すことを示した.この際,増殖期細胞(P細胞)がQ細胞にシフトしていることも明らかにした.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Agents (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Cycle (日) (読) [継承]
5. (英) Cell Division (日) (読) [継承]
6. (英) Dose-Response Relationship, Drug (日) (読) [継承]
7. (英) Drug Administration Schedule (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Injections, Intraperitoneal (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred C3H (日) (読) [継承]
12. (英) Micronuclei, Chromosome-Defective (日) (読) [継承]
13. (英) Neoplasm Transplantation (日) (読) [継承]
14. (英) Triazines (日) (読) [継承]
15. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Japanese Journal of Cancer Research ([日本癌学会])
(pISSN: 0910-5050)

ISSN (任意): 0910-5050
ISSN: 0910-5050 (pISSN: 0910-5050, eISSN: 1876-4673)
Title: Japanese journal of cancer research : Gann
Title(ISO): Jpn. J. Cancer Res.
Supplier: 日本癌学会
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 731 736 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 7月 1日 (平成 12年 7月 1日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1349-7006.2000.tb01006.x    (→Scopusで検索) [継承]
PMID (任意): 10920281    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0033860907 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Soko Kasai, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration, Japanese Journal of Cancer Research, Vol.91, No.7, 731-736, 2000.
欧文冊子 ● Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Soko Kasai, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration, Japanese Journal of Cancer Research, Vol.91, No.7, 731-736, 2000.

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