『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 徳島大学以外での国内共著 (徳島大学以外でのある一つの国に属する複数機関による共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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[継承]
2. (英) Ono Koji (日) (読)
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[継承]
3.堀 均
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[継承]
4. (英) Suzuki Minoru (日) (読)
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[継承]
5. (英) Kinashi Yuko (日) (読)
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[継承]
6. (英) Takagaki Masao (日) (読)
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[継承]
7. (英) Kasai Soko (日) (読)
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[継承]
8.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意): (英)   (日) TPZの合成を担当   [継承]
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学籍番号 (推奨):
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9.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Change in oxygenation status in intratumour total and quienscent cells following γ-ray irradiation,tirapazamine administration, cisplatin injection and bleomycin treatment  (日)    [継承]
副題 (任意):
要約 (任意): (英) C3H/He mice bearing SCC VII tumours received 5-bromo-2'-deoxyuridine (BrdU) continuously for 5 days via implanted mini-osmotic pumps to label all proliferating (P) cells. The mice then received gamma-ray irradiation, or administration of tirapazamine (TPZ), cisplatin or bleomycin. At various time points after each treatment, tumour-bearing mice were irradiated with a series of test doses of gamma-rays, while alive or after being killed, to obtain hypoxic fractions (HFs) in the tumours. Immediately after gamma-ray test irradiation, the tumours were excised, minced and trypsinized. Tumour cell suspensions obtained were incubated with cytochalasin-B, a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labelling (i.e. quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. MN frequency in the total (P + Q) tumour cells was determined from the tumours that were not pre-treated with BrdU. MN frequency of BrdU-unlabelled cells was then used to calculate the surviving fraction of the unlabelled cells from the regression line for the relationship between the MN frequency and the surviving fraction of total tumour cells. TPZ and cisplatin reduced the HF after treatment, especially in Q cells, and this tendency was particularly marked with TPZ. In contrast, bleomycin increased the HF after treatment. Both reoxygenation following gamma-ray irradiation or bleomycin treatment and a subsequent return to pre-treatment levels of HF following TPZ or cisplatin treatment (rehypoxiation) occurred more rapidly in total (P + Q) cells than in Q cells. Based on our previous report that total (P + Q) and Q cells within this tumour have large acutely and chronically HFs, respectively, we conclude that acute hypoxic cells play a major role in reoxygenation and rehypoxiation in SCC VII tumours.  (日) 本論文では,腫瘍移殖担癌マウスモデルに対して,放射線,TPZ,シスプラチン投与,ブレオマイシン処理を行った場合の,総腫瘍細胞またはQ細胞における酸素化ステータスの変化を調べた.この結果TPZはQ細胞における低酸素分画を減少させることを示した.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibiotics, Antineoplastic (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Bleomycin (日) (読) [継承]
5. (英) Bromodeoxyuridine (日) (読) [継承]
6. (英) Carcinoma, Squamous Cell (日) (読) [継承]
7. (英) Cell Hypoxia (日) (読) [継承]
8. (英) Cisplatin (日) (読) [継承]
9. (英) Cytochalasin B (日) (読) [継承]
10. (英) Injections (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Micronucleus Tests (日) (読) [継承]
13. (英) Triazines (日) (読) [継承]
14. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The British Journal of Radiology (British Institute of Radiology)
(pISSN: 0007-1285, eISSN: 1748-880X)

ISSN (任意): 0007-1285
ISSN: 0007-1285 (pISSN: 0007-1285, eISSN: 1748-880X)
Title: The British journal of radiology
Title(ISO): Br J Radiol
Supplier: British Institute of Radiology
Publisher: British Institute of Radiology
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 73 [継承]
(必須): 873 [継承]
(必須): 978 986 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 9月 1日 (平成 12年 9月 1日) [継承]
URL (任意):
DOI (任意): 10.1259/bjr.73.873.11064652    (→Scopusで検索) [継承]
PMID (任意): 11064652    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000089702500010 [継承]
Scopus (任意): 2-s2.0-0033819629 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Koji Ono, Hitoshi Hori, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Soko Kasai, Hideko Nagasawa and Yoshihiro Uto : Change in oxygenation status in intratumour total and quienscent cells following γ-ray irradiation,tirapazamine administration, cisplatin injection and bleomycin treatment, The British Journal of Radiology, Vol.73, No.873, 978-986, 2000.
欧文冊子 ● Shin-ichiro Masunaga, Koji Ono, Hitoshi Hori, Minoru Suzuki, Yuko Kinashi, Masao Takagaki, Soko Kasai, Hideko Nagasawa and Yoshihiro Uto : Change in oxygenation status in intratumour total and quienscent cells following γ-ray irradiation,tirapazamine administration, cisplatin injection and bleomycin treatment, The British Journal of Radiology, Vol.73, No.873, 978-986, 2000.

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