『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=159584)

EID=159584EID:159584, Map:0, LastModified:2012年10月29日(月) 21:04:47, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[長谷川 敬展], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1. (英) Nakashima Akio (日) (読) なかしま あきお
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2.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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3. (英) Mori Saori (日) (読) もり さおり
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4. (英) Ueno Masaru (日) 上野 勝 (読) うえの まさる
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5. (英) Tanaka Shigeyasu (日) 田中 滋康 (読) たなか しげやす
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6. (英) Ushimaru Takashi (日) 丑丸 敬 (読) うしまる たかし
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7. (英) Sato Shusei (日) (読)
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8. (英) Uritani Masahiro (日) 瓜谷 真裕 (読) うりたに まさひろ
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題名 (必須): (英) A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Schizosaccharomyces pombe isp6(+) gene encodes a vacuolar serine protease, which is specifically induced during nitrogen starvation. An isp6-disruption mutant, isp6Delta, grew normally under normal conditions but was defective in large-scale protein degradation during nitrogen starvation, a hallmark of autophagy. Vacuoles are the organelles for such drastic protein degradation but those of isp6Delta were apparently aberrant. isp6Delta was infertile under nitrogen source-free conditions with poor expression of ste11(+), a gene critical for sexual development. A protein kinase A-disruption mutant, pka1Delta, is prone to sexual development because expression of ste11(+) is derepressed. However, isp6Deltapka1Delta still showed defects in ste11(+) expression and sexual development under nitrogen source-free conditions. isp6Delta and isp6Deltapka1Delta were able to initiate sexual development to produce spores when only a small amount of a nitrogen source was present. Pat1 protein kinase negatively controls meiosis, and a temperature-sensitive mutant of pat1, pat1-114, initiates meiosis irrespective of ploidy at the restrictive temperature. However, isp6Deltapat1-114 did not start meiosis under nitrogen source-free conditions even at the restrictive temperature. These observations suggest that isp6(+) contributes to sexual development by providing a nitrogen source through autophagy.  (日)    [継承]
キーワード (推奨): 1. (英) Autophagy (日) (読) [継承]
2. (英) Epistasis, Genetic (日) (読) [継承]
3. (英) Gene Expression Regulation, Fungal (日) (読) [継承]
4. (英) Meiosis (日) (読) [継承]
5. (英) Membrane Proteins (日) (読) [継承]
6. (英) Nitrogen (日) (読) [継承]
7. (英) Schizosaccharomyces (日) (読) [継承]
8. (英) Schizosaccharomyces pombe Proteins (日) (読) [継承]
9. (英) Serine Endopeptidases (日) (読) [継承]
10. (英) Signal Transduction (日) (読) [継承]
11. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨): (英) Springer International (日) (読) [継承]
誌名 (必須): Current Genetics ([Springer-Verlag])
(pISSN: 0172-8083, eISSN: 1432-0983)

ISSN (任意): 0172-8083
ISSN: 0172-8083 (pISSN: 0172-8083, eISSN: 1432-0983)
Title: Current genetics
Title(ISO): Curr Genet
Supplier: Springer Online Journal Archive
Publisher: Springer
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(必須): 49 [継承]
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年月日 (必須): 西暦 2006年 6月 初日 (平成 18年 6月 初日) [継承]
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DOI (任意): 10.1007/s00294-006-0067-0    (→Scopusで検索) [継承]
PMID (任意): 16550352    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, 422-8539, Shizuoka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akio Nakashima, Takahiro Hasegawa, Saori Mori, Masaru Ueno, Shigeyasu Tanaka, Takashi Ushimaru, Shusei Sato and Masahiro Uritani : A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe., Current Genetics, Vol.49, No.6, 403-413, 2006.
欧文冊子 ● Akio Nakashima, Takahiro Hasegawa, Saori Mori, Masaru Ueno, Shigeyasu Tanaka, Takashi Ushimaru, Shusei Sato and Masahiro Uritani : A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe., Current Genetics, Vol.49, No.6, 403-413, 2006.

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