『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=159022EID:159022, Map:0, LastModified:2012年10月29日(月) 11:46:47, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[近久 幸子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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2.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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3. (英) Morishima Masaki (日) 森島 真幸 (読) もりしま まさき
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4.佐野 敦子
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5.北岡 和義 ([徳島大学.教養教育院])
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6.中屋 豊
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7.森田 雄介
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題名 (必須): (英) Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Music has been suggested to have a beneficial effect on various types of performance in humans. However, the physiological and molecular mechanism of this effect remains unclear. We examined the effect of music exposure during the perinatal period on learning behavior in adult mice, and measured the levels of brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), which play critical roles in synaptic plasticity. In addition, we measured the levels of 3-phosphoinositide-dependent protein kinase-1 (PDK1) and mitogen-activated protein kinase (MAPK), downstream targets of two main pathways in BDNF/TrkB signaling. Music-exposed mice completed a maze learning task with fewer errors than the white noise-exposed mice and had lower levels of BDNF and higher levels of TrkB and PDK1 in the cortex. MAPK levels were unchanged. Furthermore, TrkB and PDK1 protein levels in the cortex showed a significant negative correlation with the number of errors on the maze. These results suggest that perinatal exposure of mice to music has an influence on BDNF/TrkB signaling and its intracellular signaling pathway targets, including PDK1, and thus may induce improved learning and memory functions.  (日)    [継承]
キーワード (推奨): 1. (英) Learning (日) (読) [継承]
2. (英) Music (日) (読) [継承]
3. (英) BDNF (日) (読) [継承]
4. (英) TrkB (日) (読) [継承]
5. (英) MAPK (日) (読) [継承]
6. (英) PDK1 (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Behavioural Brain Research ([Elsevier])
(pISSN: 0166-4328, eISSN: 1872-7549)

ISSN (任意): 0166-4328
ISSN: 0166-4328 (pISSN: 0166-4328, eISSN: 1872-7549)
Title: Behavioural brain research
Title(ISO): Behav. Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2006年 5月 初日 (平成 18年 5月 初日) [継承]
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DOI (任意): 10.1016/j.bbr.2006.01.021    (→Scopusで検索) [継承]
PMID (任意): 16530277    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita : Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults., Behavioural Brain Research, Vol.169, No.2, 312-319, 2006.
欧文冊子 ● Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita : Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults., Behavioural Brain Research, Vol.169, No.2, 312-319, 2006.

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