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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.新田 剛
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2.高浜 洋介
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題名 (必須): (英) The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins  (日)    [継承]
副題 (任意):
要約 (任意): (英) The life-or-death decision of immune cells makes an essential contribution to immune-system development and the regulation of immune responses. A new family of cell-survival regulators expressed in lymphocytes, termed immune-associated nucleotide-binding proteins (IANs) [also known as GTPase of immunity-associated proteins (GIMAPs)], has been described. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens (日) (読) [継承]
3. (英) Cell Survival (日) (読) [継承]
4. (英) GTP-Binding Proteins (日) (読) [継承]
5. (英) Gene Expression Regulation (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Lymphocytes (日) (読) [継承]
8. (英) Receptors, Immunologic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Trends in Immunology (Cell Press)
(pISSN: 1471-4906, eISSN: 1471-4981)

ISSN (任意): 1471-4906
ISSN: 1471-4906 (pISSN: 1471-4906, eISSN: 1471-4981)
Title: Trends in immunology
Title(ISO): Trends Immunol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 0月 初日 (平成 19年 0月 初日) [継承]
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DOI (任意): 10.1016/j.it.2006.12.002    (→Scopusで検索) [継承]
PMID (任意): 17196432    (→Scopusで検索) [継承]
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WOS (任意): 000244374800004 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 66  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nitta and Yousuke Takahama : The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins, Trends in Immunology, Vol.28, No.2, 58-65, 2007.
欧文冊子 ● Takeshi Nitta and Yousuke Takahama : The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins, Trends in Immunology, Vol.28, No.2, 58-65, 2007.

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