『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=154926EID:154926, Map:0, LastModified:2013年6月10日(月) 14:04:19, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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2.奥村 裕司
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学籍番号 (推奨):
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3.山田 博司
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学籍番号 (推奨):
[継承]
4. (英) Trong Q. Le (日) (読)
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学籍番号 (推奨):
[継承]
5.矢野 仁康
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Proteases Essential for Human Influenza Virus Entry into Cells and Their Inhibitors as Potential Therapeutic Agents  (日)    [継承]
副題 (任意):
要約 (任意): (英) Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since IVA genome does not have the processing protease for the viral membrane fusion glycoprotein precursors, entry of this virus into cells is determined primarily by host cellular, trypsin-type, processing proteases that proteolytically activate the fusion glycoprotein precursors of IAV. At least five different processing proteases have been identified in the airways of animals and humans. These proteases determine the infectious organ tropism of IAV infection as well as the efficiency of viral multiplication in the airway, and sometimes in the brain. Proteases in the upper respiratory tract are suppressed by secretory leukoprotease inhibitor, and those in the lower respiratory tract are suppressed by pulmonary surfactant which, by adsorption, inhibits the interaction between the proteases and viral membrane proteins. Since protease activities predominate over those of endogenous inhibitory compounds under normal airway conditions, administration of protease inhibitors in the early-stage of infection significantly suppresses viral entry and viral multiplication. Several viral neuraminidase inhibitors are used clinically as anti-influenza virus agents, based on their inhibitory action on viral release from infected cells. Furthermore, protease inhibitors of viral entry could be potentially useful against influenza virus as well as neuraminidase inhibitor-resistant viruses. We also found that ambroxol, a mucolytic and anti-oxidant agent, up-regulates the levels of endogenous protease inhibitory compounds in the airway fluids in early-phase infection, and that clarithromycin, a macrolide antibiotic, increases IgA levels and mucosal immunity through augmentation of interleukin-12 levels in the airway. The combination of neuraminidase inhibitors and protease inhibitors, clarithromycin or ambroxol, could be potentially used as a potent anti-influenza therapy to minimize the emergence of drug-resistant mutant viruses.  (日)    [継承]
キーワード (推奨): 1. (英) Ambroxol (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antiviral Agents (日) (読) [継承]
4. (英) Brain (日) (読) [継承]
5. (英) Clarithromycin (日) (読) [継承]
6. (英) Drug Therapy, Combination (日) (読) [継承]
7. (英) Expectorants (日) (読) [継承]
8. (英) Hemagglutinin Glycoproteins, Influenza Virus (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Influenza A virus (日) (読) [継承]
11. (英) Influenza, Human (日) (読) [継承]
12. (英) Neuraminidase (日) (読) [継承]
13. (英) Peptide Hydrolases (日) (読) [継承]
14. (英) Protease Inhibitors (日) (読) [継承]
15. (英) Protein Processing, Post-Translational (日) (読) [継承]
16. (英) Pulmonary Surfactants (日) (読) [継承]
17. (英) Respiratory System (日) (読) [継承]
18. (英) Secretory Leukocyte Peptidase Inhibitor (日) (読) [継承]
19. (英) Virus Replication (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Current Pharmaceutical Design (Bentham Science Publishers)
(pISSN: 1381-6128, eISSN: 1873-4286)

ISSN (任意): 1873-4286
ISSN: 1381-6128 (pISSN: 1381-6128, eISSN: 1873-4286)
Title: Current pharmaceutical design
Title(ISO): Curr Pharm Des
Publisher: Bentham Science Publishers
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 13 [継承]
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(必須): 405 414 [継承]
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年月日 (必須): 西暦 2007年 4月 1日 (平成 19年 4月 1日) [継承]
URL (任意):
DOI (任意): 10.2174/138161207780162971    (→Scopusで検索) [継承]
PMID (任意): 17311557    (→Scopusで検索) [継承]
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WOS (任意): 000245200900005 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan. kido@ier.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 58  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Kido, Yuushi Okumura, Hiroshi Yamada, Le Q. Trong and Mihiro Yano : Proteases Essential for Human Influenza Virus Entry into Cells and Their Inhibitors as Potential Therapeutic Agents, Current Pharmaceutical Design, Vol.13, No.4, 405-414, 2007.
欧文冊子 ● Hiroshi Kido, Yuushi Okumura, Hiroshi Yamada, Le Q. Trong and Mihiro Yano : Proteases Essential for Human Influenza Virus Entry into Cells and Their Inhibitors as Potential Therapeutic Agents, Current Pharmaceutical Design, Vol.13, No.4, 405-414, 2007.

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