『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=154923EID:154923, Map:0, LastModified:2013年11月11日(月) 16:05:19, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1.矢野 仁康
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学籍番号 (推奨):
[継承]
2. (英) S. Nakamuta (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) X. Wu (日) (読)
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学籍番号 (推奨):
[継承]
4.奥村 裕司
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学籍番号 (推奨):
[継承]
5.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) A novel function of 14-3-3 protein: 14-3-3z is a heat shock-related molecular chaperone that dissolves thermal-aggregated proteins  (日)    [継承]
副題 (任意):
要約 (任意): (英) The 14-3-3 proteins are highly conserved molecules that function as intracellular adaptors in a variety of biological processes, such as signal transduction, cell cycle control, and apoptosis. Here, we show that a 14-3-3 protein is a heat-shock protein (Hsp) that protects cells against physiological stress as its new cellular function. We have observed that, in Drosophila cells, the 14-3-3zeta is up-regulated under heat stress conditions, a process mediated by a heat shock transcription factor. As the biological action linked to heat stress, 14-3-3zeta interacted with apocytochrome c, a mitochondrial precursor protein of cytochrome c, in heat-treated cells, and the suppression of 14-3-3zeta expression by RNA interference resulted in the formation of significant amounts of aggregated apocytochrome c in the cytosol. The aggregated apocytochrome c was converted to a soluble form by the addition of 14-3-3zeta protein and ATP in vitro. 14-3-3zeta also resolubilized heat-aggregated citrate synthase and facilitated its reactivation in cooperation with Hsp70/Hsp40 in vitro. Our observations provide the first direct evidence that a 14-3-3 protein functions as a stress-induced molecular chaperone that dissolves and renaturalizes thermal-aggregated proteins.  (日)    [継承]
キーワード (推奨): 1. (英) 14-3-3 Proteins (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Citrate (si)-Synthase (日) (読) [継承]
4. (英) Cytochromes c (日) (読) [継承]
5. (英) Cytosol (日) (読) [継承]
6. (英) Drosophila (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) HSP40 Heat-Shock Proteins (日) (読) [継承]
9. (英) HSP70 Heat-Shock Proteins (日) (読) [継承]
10. (英) Heat-Shock Response (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Hyperthermia, Induced (日) (読) [継承]
13. (英) Mitochondrial Proteins (日) (読) [継承]
14. (英) Molecular Chaperones (日) (読) [継承]
15. (英) Protein Precursors (日) (読) [継承]
16. (英) Protein Structure, Quaternary (日) (読) [継承]
17. (英) Protein Transport (日) (読) [継承]
18. (英) RNA Interference (日) (読) [継承]
19. (英) RNA, Messenger (日) (読) [継承]
20. (英) Recombinant Proteins (日) (読) [継承]
21. (英) Solubility (日) (読) [継承]
22. (英) Temperature (日) (読) [継承]
23. (英) Transcription, Genetic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Biology of the Cell (The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)

ISSN (任意): 1059-1524
ISSN: 1059-1524 (pISSN: 1059-1524, eISSN: 1939-4586)
Title: Molecular biology of the cell
Title(ISO): Mol Biol Cell
Publisher: American Society for Cell Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 17 [継承]
(必須): 11 [継承]
(必須): 4769 4779 [継承]
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年月日 (必須): 西暦 2006年 4月 7日 (平成 18年 4月 7日) [継承]
URL (任意):
DOI (任意): 10.1091/mbc.E06-03-0229    (→Scopusで検索) [継承]
PMID (任意): 16943323    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1635386  (日)    [継承]

標準的な表示

和文冊子 ● Mihiro Yano, Nakamuta S., Wu X., Yuushi Okumura and Hiroshi Kido : A novel function of 14-3-3 protein: 14-3-3z is a heat shock-related molecular chaperone that dissolves thermal-aggregated proteins, Molecular Biology of the Cell, Vol.17, No.11, 4769-4779, 2006.
欧文冊子 ● Mihiro Yano, Nakamuta S., Wu X., Yuushi Okumura and Hiroshi Kido : A novel function of 14-3-3 protein: 14-3-3z is a heat shock-related molecular chaperone that dissolves thermal-aggregated proteins, Molecular Biology of the Cell, Vol.17, No.11, 4769-4779, 2006.

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