『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=154899)

EID=154899EID:154899, Map:0, LastModified:2012年9月3日(月) 17:37:40, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Kitamura H. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Cui Ping (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Sharmin S. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.矢野 仁康
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学籍番号 (推奨):
[継承]
5.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ETB or ETB-like receptor in porcine lungs.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Endothelin-1-(1-31) is a new bioactive 31-amino-acid-length peptide generated from big endothelin-1 by chymase or other chymotrypsin-type proteases with various pathophysiologic functions. In this study, we have detected the specific and monophasic binding of [125I]endothelin-1-(1-31) in porcine lung membranes. Competition studies of [125I]endothelin-1-(1-31) binding by unlabeled endothelin-1-(1-31), endothelin-1, endothelin-3, and antagonists and agonists of endothelin ET(A) and ET(B) receptors suggest that the binding protein is an endothelin ET(B) or ET(B)-like receptor rather than an endothelin ET(A) receptor in porcine lungs. Kinetic studies showed that the affinity of endothelin-1-(1-31) to its receptor was approximately one order of magnitude lower than that of endothelin-1, and that the specific binding of endothelin-1-(1-31) was about 19% of endothelin-1 binding. The binding of [125I]endothelin-1-(1-31) was extremely slow, slower even than that of endothelin-1, and nearly irreversible. This unique quasi-irreversibility may explain the slow-onset and long-lasting biologic effects of this peptide in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Binding, Competitive (日) (読) [継承]
3. (英) Cell Membrane (日) (読) [継承]
4. (英) Dose-Response Relationship, Drug (日) (読) [継承]
5. (英) Endothelin-1 (日) (読) [継承]
6. (英) Endothelin-3 (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Glycopeptides (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Iodine Radioisotopes (日) (読) [継承]
11. (英) Lung (日) (読) [継承]
12. (英) Metalloendopeptidases (日) (読) [継承]
13. (英) Oligopeptides (日) (読) [継承]
14. (英) Peptide Fragments (日) (読) [継承]
15. (英) Peptides, Cyclic (日) (読) [継承]
16. (英) Piperidines (日) (読) [継承]
17. (英) Radioligand Assay (日) (読) [継承]
18. (英) Receptor, Endothelin B (日) (読) [継承]
19. (英) Receptors, Endothelin (日) (読) [継承]
20. (英) Swine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Journal of Pharmacology ([Elsevier])
(pISSN: 0014-2999, eISSN: 1879-0712)

ISSN (任意): 0014-2999
ISSN: 0014-2999 (pISSN: 0014-2999, eISSN: 1879-0712)
Title: European journal of pharmacology
Title(ISO): Eur J Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 465 [継承]
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(必須): 31 38 [継承]
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年月日 (必須): 西暦 2003年 4月 4日 (平成 15年 4月 4日) [継承]
URL (任意):
DOI (任意): 10.1016/S0014-2999(03)01454-7    (→Scopusで検索) [継承]
PMID (任意): 12650830    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● H. Kitamura, Ping Cui, S. Sharmin, Mihiro Yano and Hiroshi Kido : Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ETB or ETB-like receptor in porcine lungs., European Journal of Pharmacology, Vol.465, No.1-2, 31-38, 2003.
欧文冊子 ● H. Kitamura, Ping Cui, S. Sharmin, Mihiro Yano and Hiroshi Kido : Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ETB or ETB-like receptor in porcine lungs., European Journal of Pharmacology, Vol.465, No.1-2, 31-38, 2003.

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