『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=154897)

EID=154897EID:154897, Map:0, LastModified:2024年12月6日(金) 16:54:46, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
○著者 (必須): 1. (英) Yao Dengfu (日) (読)
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○学籍番号 (推奨):
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2.桒島 正道
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3.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The pathogenesis of influenza encephalopathy or encephalitis is poorly understood. This review summarizes our recent studies of the roles played by inflammatory cytokines, inducible nitric oxide synthase (iNOS), adhesion molecules and mini-plasmin in influenza encephalitis. After the intranasal infection of newborn mice with the non-neurotropic strain of influenza A virus (IAV) Aichi/2/68/H3N2, encephalitis and severe brain edema were observed within 3-5 days. IAV-RNA and abnormalities in the blood-brain barrier permeability were detected in association with an increase in the mRNA expressions of endothelin-1, iNOS, and tumor necrosis factor-alpha. Furthermore, the accumulation in the brain capillaries of mini-plasmin, which proteolytically induces the viral envelope fusion activity and allows the virus to enter the cells, changes the brain from non-susceptible to susceptible to non-neurotropic IAV multiplication. The accumulation of mini-plasmin was markedly greater in newborn mice with an impaired mitochondrial fatty acid metabolism. These inflammatory mediators and the accumulation of mini-plasmin in the brain may play an important role in the onset and progression of LAV encephalitis.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Newborn (日) (読) [継承]
3. (英) Anti-Inflammatory Agents, Non-Steroidal (日) (読) [継承]
4.血液脳関門 (blood-brain barrier) [継承]
5. (英) Brain Edema (日) (読) [継承]
6.細胞質分裂 (cytokinesis) [継承]
7. (英) Encephalitis, Viral (日) (読) [継承]
8. (英) Endothelins (日) (読) [継承]
9. (英) Fatty Acids (日) (読) [継承]
10. (英) Fibrinolysin (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Inflammation Mediators (日) (読) [継承]
13. (英) Influenza A virus (日) (読) [継承]
14. (英) Influenza, Human (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16.ノックアウトマウス (knockout mice) [継承]
17.ミトコンドリア (mitochondria) [継承]
18.一酸化窒素 (nitric oxide) [継承]
19. (英) Nitric Oxide Synthase (日) (読) [継承]
20. (英) Nitric Oxide Synthase Type II (日) (読) [継承]
21.酸化ストレス (oxidative stress) [継承]
22. (英) Peptide Fragments (日) (読) [継承]
23. (英) Protein Isoforms (日) (読) [継承]
24. (英) Reye Syndrome (日) (読) [継承]
25. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
26. (英) Virulence (日) (読) [継承]
○発行所 (推奨): □徳島大学 [継承]
○誌名 (必須): □The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

○ISSN (任意): □1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: University of Tokushima
 (NLM Catalog)   (Webcat Plus)   (医中誌Web)   (J-STAGE)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □50 [継承]
○号 (必須): □1-2 [継承]
○頁 (必須): □1 8 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2003年 4月 2日 (平成 15年 4月 2日) [継承]
○URL (任意): □http://ci.nii.ac.jp/naid/110001902031/ [継承]
○DOI (任意):
○PMID (任意): □12630563    (→Scopusで検索) [継承]
○CRID (任意): □1050583647830728320 [継承]
○NAID : □110001902031 [継承]
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○Scopus (任意):
○機関リポジトリ : □110672 [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 35  (日)    [継承]

標準的な表示

和文冊子 ● Dengfu Yao, Masamichi Kuwajima and Hiroshi Kido : Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin, The Journal of Medical Investigation : JMI, Vol.50, No.1-2, 1-8, 2003.
欧文冊子 ● Dengfu Yao, Masamichi Kuwajima and Hiroshi Kido : Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin, The Journal of Medical Investigation : JMI, Vol.50, No.1-2, 1-8, 2003.

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