『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=154891)

EID=154891EID:154891, Map:0, LastModified:2013年11月11日(月) 16:05:19, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Yang Bing (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yao Fu Deng (日) (読)
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[継承]
3. (英) Ohuchi M. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Ide M. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.矢野 仁康
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学籍番号 (推奨):
[継承]
6.奥村 裕司
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学籍番号 (推奨):
[継承]
7.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Ambroxol suppresses influenza-virus proliferation in the mouse airway by incresing antiviral factor levels  (日)    [継承]
副題 (任意):
要約 (任意): (英) The protective effect of ambroxol, a mucolytic agent which has antioxidant properties and stimulates the release of pulmonary surfactant, against influenza-virus proliferation in the airway was investigated in mice. Ambroxol or the vehicle was administered intraperitoneally twice a day for 5-7 days to mice shortly after intranasal infection with a lethal dose of influenza A/Aichi/68 (H3N2) virus, and the survival rate, virus titre and levels of factors regulating virus proliferation in the airway fluid were analysed. Ambroxol significantly suppressed virus multiplication and improved the survival rate of mice. The effect of ambroxol reached a peak at 10 mg x kg(-1) x day(-1), higher doses being less effective. Ambroxol stimulated the release of suppressors of influenza-virus multiplication, such as pulmonary surfactant, mucus protease inhibitor, immunoglobulin (Ig)-A and IgG, although it stimulated the release of a trypsin-type protease that potentiates virus proliferation. In addition, ambroxol transiently suppressed release of the cytokines, tumour necrosis factor-alpha, interferon-gamma and interleukin-12, into airway fluid. Although ambroxol had several negative effects on the host defence system, overall it strikingly increased the concentrations of suppressors of influenza-virus multiplication in the airway.  (日)    [継承]
キーワード (推奨): 1. (英) Ambroxol (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Bronchoalveolar Lavage Fluid (日) (読) [継承]
4. (英) Cytokines (日) (読) [継承]
5. (英) Expectorants (日) (読) [継承]
6. (英) Immunoglobulins (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Orthomyxoviridae (日) (読) [継承]
9. (英) Orthomyxoviridae Infections (日) (読) [継承]
10. (英) Pulmonary Surfactants (日) (読) [継承]
11. (英) Respiratory Tract Infections (日) (読) [継承]
12. (英) Survival Analysis (日) (読) [継承]
13. (英) Virus Replication (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The European Respiratory Journal (European Society for Clinical Respiratory Physiology/European Respiratory Society)
(pISSN: 0903-1936, eISSN: 1399-3003)

ISSN (任意): 0903-1936
ISSN: 0903-1936 (pISSN: 0903-1936, eISSN: 1399-3003)
Title: The European respiratory journal
Title(ISO): Eur Respir J
Publisher: European Respiratory Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 19 [継承]
(必須): 5 [継承]
(必須): 952 958 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 4月 1日 (平成 14年 4月 1日) [継承]
URL (任意):
DOI (任意): 10.1183/09031936.02.00253302    (→Scopusで検索) [継承]
PMID (任意): 12030738    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Evaluation Studies  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Bing Yang, Deng Fu Yao, M. Ohuchi, M. Ide, Mihiro Yano, Yuushi Okumura and Hiroshi Kido : Ambroxol suppresses influenza-virus proliferation in the mouse airway by incresing antiviral factor levels, The European Respiratory Journal, Vol.19, No.5, 952-958, 2002.
欧文冊子 ● Bing Yang, Deng Fu Yao, M. Ohuchi, M. Ide, Mihiro Yano, Yuushi Okumura and Hiroshi Kido : Ambroxol suppresses influenza-virus proliferation in the mouse airway by incresing antiviral factor levels, The European Respiratory Journal, Vol.19, No.5, 952-958, 2002.

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