『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=154889)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) H. Wakabayashi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2.矢野 仁康
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[継承]
3. (英) N. Tachikawa (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) S. Oka (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) M. Maeda (日) (読)
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6.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Increased concentrations of 14-3-3ϵ,γ and ζ isoforms in cerebrospinal fluid ofAIDS patients with neuronal destruction  (日)    [継承]
副題 (任意):
要約 (任意): (英) 14-3-3 proteins are major evolutionarily conserved cytosolic proteins that regulate signal transduction, apoptosis and neurotransmitter synthesis. Five homologous 14-3-3 isoforms, beta, gamma, zeta, epsilon and eta, are reported in mammalian neurones. To elucidate the diagnostic value of 14-3-3 in cerebrospinal fluid (CSF), a highly specific antibody against each isoform and studies on the isoform patterns in patients with neuronal destruction are needed. In this study, we raised isoform-specific antibodies against 14-3-3 proteins and established a semiquantitative method of identification of each isoform by Western immunoblotting. We found that three isoforms, 14-3-3 epsilon, gamma and zeta, appeared in the CSF of HIV patients with AIDS dementia complex or cytomegalovirus encephalitis, but not in AIDS patients without neurological symptoms or the non-HIV patients examined. The isoform patterns in AIDS patients were different from those reported in Creutzfeldt-Jakob disease and herpes simplex encephalitis, suggesting that the isoform patterns may facilitate the differential diagnosis. A high frequency of 14-3-3 in CSF was observed in seriously ill AIDS patients, particularly those with CD4 levels of less than 20 mm(3). These findings suggested that 14-3-3 proteins were released from destroyed neural cells and are useful real-time markers of the rate and amount of neural cell destruction in these patients.  (日)    [継承]
キーワード (推奨): 1. (英) 14-3-3 Proteins (日) (読) [継承]
2. (英) Acquired Immunodeficiency Syndrome (日) (読) [継承]
3. (英) Adult (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Case-Control Studies (日) (読) [継承]
6. (英) Cytomegalovirus Infections (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Meningitis, Cryptococcal (日) (読) [継承]
9. (英) Middle Aged (日) (読) [継承]
10. (英) Neurons (日) (読) [継承]
11. (英) Predictive Value of Tests (日) (読) [継承]
12. (英) Protein Isoforms (日) (読) [継承]
13. (英) Serine Endopeptidases (日) (読) [継承]
14. (英) Tyrosine 3-Monooxygenase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinica Chimica Acta ([Elsevier])
(pISSN: 0009-8981, eISSN: 1873-3492)

ISSN (任意): 0009-8981
ISSN: 0009-8981 (pISSN: 0009-8981, eISSN: 1873-3492)
Title: Clinica chimica acta; international journal of clinical chemistry
Title(ISO): Clin Chim Acta
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 97 105 [継承]
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年月日 (必須): 西暦 2001年 4月 7日 (平成 13年 4月 7日) [継承]
URL (任意):
DOI (任意): 10.1016/S0009-8981(01)00595-2    (→Scopusで検索) [継承]
PMID (任意): 11580914    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Wakabayashi H., Mihiro Yano, Tachikawa N., Oka S., Maeda M. and Hiroshi Kido : Increased concentrations of 14-3-3ϵ,γ and ζ isoforms in cerebrospinal fluid ofAIDS patients with neuronal destruction, Clinica Chimica Acta, Vol.312, No.1-2, 97-105, 2001.
欧文冊子 ● Wakabayashi H., Mihiro Yano, Tachikawa N., Oka S., Maeda M. and Hiroshi Kido : Increased concentrations of 14-3-3ϵ,γ and ζ isoforms in cerebrospinal fluid ofAIDS patients with neuronal destruction, Clinica Chimica Acta, Vol.312, No.1-2, 97-105, 2001.

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