『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=154852)

EID=154852EID:154852, Map:0, LastModified:2017年4月15日(土) 20:06:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Nakano A. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kishi F. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Minami K. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Wakabayashi H. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Nakaya Y. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Selective Conversion of Big Endothelins to Tracheal Smooth Muscle-Constricting 31-Amino Acid Length Endothelins by Chymase from Human Mast Cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products. Chymases from other species, such as the enzymes from rat connective tissue and mucosal mast cells, and the other chymotrypsin-like proteases examined degraded big ETs. ETs(1-31) exhibited various contractile potencies as to the rat trachea in comparison with 21-amino acid-length endothelins, ETs(1-21), and big ETs: ET-1(1-21) > ET-1(1-31) > big ET-1; ET-2(1-31) > ET-2(1-21) > or = big ET-2; ET-3(1-21) > or = ET-3(1-31) > or = big ET-3. Among the ETs(1-31), ET-2(1-31) was the most potent constrictor, its potency being similar to that of ET-1(1-21) and stronger than that of ET-2(1-21). The contractile activity of ETs(1-31) may not be the consequence of conversion to the corresponding ETs(1-21) by phosphoramidon-sensitive ET-converting enzymes or other chymotrypsin-type proteases and metalloendopeptidases, because the contractile activity was not inhibited significantly on treatment with inhibitors of these proteases before the addition of ET-1(1-31). Inhibitors of chymotrypsin-type serine proteases, on the contrary, significantly enhanced the contractile activity exhibited by ET-1(1-31) and big ET-1, but not that by ET-1(1-21). These results suggest that protease(s) on the surface of the rat trachea tends to degrade ETs(1-31) and big ETs, and thereby reduces their contractile activity. Taken together, the results suggest that trachea-constricting ETs(1-31) generated by human chymase may play a role in the hyper-responsive airway in allergic inflammation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Chymases (日) (読) [継承]
3. (英) Endothelin-1 (日) (読) [継承]
4. (英) Endothelins (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Hydrogen-Ion Concentration (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mast Cells (日) (読) [継承]
9. (英) Muscle Contraction (日) (読) [継承]
10. (英) Peptide Fragments (日) (読) [継承]
11. (英) Protease Inhibitors (日) (読) [継承]
12. (英) Protein Precursors (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Wistar (日) (読) [継承]
15. (英) Serine Endopeptidases (日) (読) [継承]
16. (英) Trachea (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 159 [継承]
(必須): 4 [継承]
(必須): 1987 1992 [継承]
都市 (任意):
年月日 (必須): 西暦 1997年 4月 6日 (平成 9年 4月 6日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 9257865    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● A. Nakano, F. Kishi, K. Minami, H. Wakabayashi, Y. Nakaya and Hiroshi Kido : Selective Conversion of Big Endothelins to Tracheal Smooth Muscle-Constricting 31-Amino Acid Length Endothelins by Chymase from Human Mast Cells, The Journal of Immunology, Vol.159, No.4, 1987-1992, 1997.
欧文冊子 ● A. Nakano, F. Kishi, K. Minami, H. Wakabayashi, Y. Nakaya and Hiroshi Kido : Selective Conversion of Big Endothelins to Tracheal Smooth Muscle-Constricting 31-Amino Acid Length Endothelins by Chymase from Human Mast Cells, The Journal of Immunology, Vol.159, No.4, 1987-1992, 1997.

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