『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=152992EID:152992, Map:0, LastModified:2012年11月3日(土) 17:47:13, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2. (英) Sakurai Yoshinori (日) (読)
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[継承]
3. (英) Nagata Kenji (日) (読)
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[継承]
4. (英) Suzuki Minoru (日) (読)
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[継承]
5. (英) Maruhashi Akira (日) (読)
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[継承]
6. (英) Kinashi Yuko (日) (読)
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7.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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8.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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9.堀 均
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10. (英) Ono Koji (日) (読)
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題名 (必須): (英) The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons  (日)    [継承]
副題 (任意):
要約 (任意): (英) We clarified the usefulness of the continuous administration of tirapazamine (TPZ) in combination with reduced dose-rate irradiation (RDRI) using gamma-rays or reactor thermal neutrons. Squamous cell carcinoma (SCC) VII tumour-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. Then, they received a single intraperitoneal injection or 24 h continuous subcutaneous infusion of TPZ in combination with conventional dose-rate irradiation (CDRI) or RDRI using gamma-rays or thermal neutrons. After irradiation, the tumour cells were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labelling ( = quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total tumour cells was determined using tumours that were not pre-treated with BrdU. The sensitivity of both total and Q cells, especially of Q cells, was significantly reduced with RDRI compared with CDRI. Combination of TPZ increased the sensitivity of both populations, with a slightly more remarkable increase in Q cells. Furthermore, the continuous administration of TPZ raised the sensitivity of both total and Q cell populations, especially the former, more markedly than the single administration, whether combined with CDRI or RDRI using gamma-rays or thermal neutrons. From the viewpoint of solid tumour control as a whole, including intratumour Q-cell control, the use of TPZ, especially when administered continuously, combined with RDRI, is useful for suppressing the reduction in the sensitivity of tumour cells caused by the decrease in irradiation dose rate in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bromodeoxyuridine (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Survival (日) (読) [継承]
5. (英) Fluorescent Antibody Technique (日) (読) [継承]
6. (英) Gamma Rays (日) (読) [継承]
7. (英) Hyperthermia, Induced (日) (読) [継承]
8. (英) Infusions, Parenteral (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C3H (日) (読) [継承]
11. (英) Micronucleus Tests (日) (読) [継承]
12. (英) Neoplasm Transplantation (日) (読) [継承]
13. (英) Neutrons (日) (読) [継承]
14. (英) Radiation-Sensitizing Agents (日) (読) [継承]
15. (英) Radiotherapy Dosage (日) (読) [継承]
16. (英) Skin Neoplasms (日) (読) [継承]
17. (英) Treatment Outcome (日) (読) [継承]
18. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The British Journal of Radiology (British Institute of Radiology)
(pISSN: 0007-1285, eISSN: 1748-880X)

ISSN (任意): 1748-880X
ISSN: 0007-1285 (pISSN: 0007-1285, eISSN: 1748-880X)
Title: The British journal of radiology
Title(ISO): Br J Radiol
Supplier: British Institute of Radiology
Publisher: British Institute of Radiology
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意):
年月日 (必須): 西暦 2006年 12月 初日 (平成 18年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1259/bjr/10893584    (→Scopusで検索) [継承]
PMID (任意): 16916808    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Yoshinori Sakurai, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori and Koji Ono : The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons, The British Journal of Radiology, Vol.79, No.948, 991-998, 2006.
欧文冊子 ● Shin-ichiro Masunaga, Yoshinori Sakurai, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori and Koji Ono : The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons, The British Journal of Radiology, Vol.79, No.948, 991-998, 2006.

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