『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=152489EID:152489, Map:0, LastModified:2012年9月4日(火) 16:40:03, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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学籍番号 (推奨):
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2.森田 恭二
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題名 (必須): (英) Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon  (日)    [継承]
副題 (任意):
要約 (任意): (英) Preclinical studies have suggested that the long-term use of antidepressants may result in the initiation and/or promotion of tumor in the gastrointestinal tract. However, a possible relationship between the use of antidepressants and the production of colon cancer has not yet been confirmed, and hence requires to be further investigated. To address this issue, the effects of antidepressants on the proliferation of colorectal tumor cells were examined using human HT29 colon carcinoma cells, and tricyclic antidepressant, such as imipramine, desipramine and amitriptyline, were shown to reduce the cell viability in a manner dependent on the time exposing to these drugs. In addition to these drugs, a selective serotonin reuptake inhibitor fluoxetine, but not a monoamine oxidase inhibitor tranylcypromine, caused the reduction of cell viability, similar in extent to that caused by imipramine. Further studies showed that desipramine caused the apoptotic cell death, which could be prevented by neither catalase, reduced-form glutathione (GSH), nor N-acetylcysteine (NAC), without accompanying the disruption of mitochondrial membrane potential within the cells and the release of cytochrome c into the cell cytoplasm. Moreover, desipramine caused the arrest of cell-cycle progression at either G0/G1-phase or G2/M-phase, which might be depending upon the drug concentration. Thus, these results suggest that tricyclic antidepressants may be cytotoxic, and induce the non-oxidative apoptotic death of human HT29 colon carcinoma cells probably through a non-mitochondrial pathway associated with the cell-cycle progression.  (日)    [継承]
キーワード (推奨): 1. (英) Amitriptyline (日) (読) [継承]
2. (英) Antidepressive Agents, Tricyclic (日) (読) [継承]
3. (英) Apoptosis (日) (読) [継承]
4. (英) Cell Cycle (日) (読) [継承]
5. (英) Cell Proliferation (日) (読) [継承]
6. (英) Cell Survival (日) (読) [継承]
7. (英) Colonic Neoplasms (日) (読) [継承]
8. (英) DNA Fragmentation (日) (読) [継承]
9. (英) Desipramine (日) (読) [継承]
10. (英) HT29 Cells (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Imipramine (日) (読) [継承]
13. (英) Membrane Potentials (日) (読) [継承]
14. (英) Mitochondrial Membranes (日) (読) [継承]
15. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Journal of Pharmacology ([Elsevier])
(pISSN: 0014-2999, eISSN: 1879-0712)

ISSN (任意): 0014-2999
ISSN: 0014-2999 (pISSN: 0014-2999, eISSN: 1879-0712)
Title: European journal of pharmacology
Title(ISO): Eur. J. Pharmacol.
Publisher: Elsevier BV
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(必須): 541 [継承]
(必須): 1-2 [継承]
(必須): 17 23 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 5月 20日 (平成 18年 5月 20日) [継承]
URL (任意):
DOI (任意): 10.1016/j.ejphar.2006.04.053    (→Scopusで検索) [継承]
PMID (任意): 16753142    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hideki Arimochi and Kyoji Morita : Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon, European Journal of Pharmacology, Vol.541, No.1-2, 17-23, 2006.
欧文冊子 ● Hideki Arimochi and Kyoji Morita : Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon, European Journal of Pharmacology, Vol.541, No.1-2, 17-23, 2006.

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