『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.有澤 孝吉
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2.上村 浩一
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学籍番号 (推奨):
[継承]
3.日吉 峰麗
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学籍番号 (推奨):
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4.武田 英雄 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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学籍番号 (推奨):
[継承]
5. (英) Saito Hiroshi (日) (読)
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[継承]
6. (英) Soda Midori (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Cadmium-induced renal dysfunction and mortality in two cohorts: diappearance of the association in a generation born later  (日)    [継承]
副題 (任意):
要約 (任意): (英) The association between exposure to environmental cadmium and mortality was investigated in two cohorts. The study population consisted of 275 (cohort I) and 329 (cohort II) residents (aged >or=40 years) in a cadmium-polluted area, Nagasaki Prefecture, Japan, who had participated in health surveys conducted in 1982 and 1992, respectively. The follow-up period extended from 1982 or 1992 to 2005. In the study area, the dietary cadmium intake had decreased after 1980-1983 because of the restoration of cadmium-polluted paddy fields. In cohort I, the mortality rate among those with urinary beta2-microglobulin (beta2-MG) concentration >or=1000 microg/g creatinine (cr.) was 1.41 times higher than the regional reference rate (95% confidence interval [CI] 1.07-1.83). After adjusting for age and other variables, in men, urinary N-acetyl-beta-D-glucosaminidase, and in women, serum creatinine, beta2-MG clearance, and urinary beta2-MG were significantly associated with increased mortality. However, in cohort II, urinary beta2-MG or total protein was not significantly associated with survival. These findings indicate that cadmium-induced renal dysfunction was a significant predictor of mortality, but that such an association is disappearing, probably because of the selective loss of advanced cases and reduced exposure and body burden.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Cadmium (日) (読) [継承]
5. (英) Cohort Studies (日) (読) [継承]
6. (英) Environmental Monitoring (日) (読) [継承]
7. (英) Environmental Pollutants (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Health Surveys (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Japan (日) (読) [継承]
12. (英) Kaplan-Meier Estimate (日) (読) [継承]
13. (英) Kidney Diseases (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Proportional Hazards Models (日) (読) [継承]
17. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Toxicology Letters ([Elsevier])
(pISSN: 0378-4274, eISSN: 1879-3169)

ISSN (任意): 0378-4274
ISSN: 0378-4274 (pISSN: 0378-4274, eISSN: 1879-3169)
Title: Toxicology letters
Title(ISO): Toxicol Lett
Publisher: Elsevier Ireland Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 169 [継承]
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(必須): 214 221 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 6月 初日 (平成 19年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.toxlet.2007.01.009    (→Scopusで検索) [継承]
PMID (任意): 17336471    (→Scopusで検索) [継承]
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評価値 (任意):
被引用数 (任意): 11 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Tokushima 770-8503, Japan. arisawa@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Hideo Takeda, Hiroshi Saito and Midori Soda : Cadmium-induced renal dysfunction and mortality in two cohorts: diappearance of the association in a generation born later, Toxicology Letters, Vol.169, No.3, 214-221, 2007.
欧文冊子 ● Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Hideo Takeda, Hiroshi Saito and Midori Soda : Cadmium-induced renal dysfunction and mortality in two cohorts: diappearance of the association in a generation born later, Toxicology Letters, Vol.169, No.3, 214-221, 2007.

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