『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=148479)

EID=148479EID:148479, Map:0, LastModified:2012年11月6日(火) 14:12:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1.大倉 一人 ([名古屋大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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学籍番号 (推奨):
[継承]
3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
4. (英) Okamura Natsuko (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Murakami Aya (日) (読)
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学籍番号 (推奨):
[継承]
6.堀 均
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The Role of Gc Protein Oligosaccharide Structure as a Risk Factor for COPD  (日)    [継承]
副題 (任意):
要約 (任意): (英) The risk of chronic obstructive pulmonary disease (COPD) is related to Gc protein allele type, such as Gc*1F, Gc*IS, Gc*2. It has been reported that Gc*1F increased COPD risk, while Gc*2 suppressed the risk. Thus, the allele type of Gc protein is an important factor in COPD. These Gc proteins differ in sugar composition at Thr418 or Thr420. In this study, features of the sugar structure of modeled Gc proteins were investigated. Gc protein (GclF, Gc1S, Gc2) models were constructed based on X-ray data of vitamin D binding protein (ID=1J7E) using InsightII-Discover with the Homology module, and the molecular orbital (MO) parameters [e.g., dipole moment, solvation free energy (dGW)] of the oligosaccharide were analyzed. The MO parameter of the sugar moiety was different for each Gc protein model. In beta-1,4 bond models, the dipole moment of Gc2 protein was larger (56.6 debye) than Gcl type (GclF: 21.9, Gc1S: 29.8 debye) protein, and it was directed towards the intermolecular space. The Gc2 oligosaccharide region was the most hydrophobic (dGW=-999.4 KI) among the Gc proteins analyzed in this study. The electrostatic potential (ESP) field of beta-1,4 type Gc2 protein was similarly distributed to beta-1,4 linked Gcl-type proteins (GclF, GclS). In the beta-1,3 type Gc protein models, the results of these parameters (i.e., dipole moment, dGW and ESP) were similar to those of beta-1,4 type models. Conclusion: The relationship between COPD risk and the features of the sugar structure in Gc proteins was examined, and it appeared that the active factors (i.e., dipole moment, dGW) might be risk factors for COPD, but passive factors (i.e., ESP) did not affect COPD risk. The bond type (beta-1,4 or beta-1,3) between galactose and N-acetylgalactosamine did not affect the molecular features.  (日)    [継承]
キーワード (推奨): 1. (英) Gc protein (日) (読) [継承]
2. (英) Gc protein-derived macrophage activating factor (GcMAF) (日) (読) [継承]
3. (英) N-acetylgalactosamine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 0250-7005
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res.
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 26 [継承]
(必須): 6A [継承]
(必須): 4073 4078 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 12月 初日 (平成 18年 12月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 17195460    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000243040200014 [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Graduate School of Bioagricultural Science, Nagoya University, Furo-cho, Chikusa-ku, Aichi 464-8601, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) MedlineDate: 2006 Nov-Dec  (日)    [継承]

標準的な表示

和文冊子 ● Kazuto Ohkura, Hideko Nagasawa, Yoshihiro Uto, Natsuko Okamura, Aya Murakami and Hitoshi Hori : The Role of Gc Protein Oligosaccharide Structure as a Risk Factor for COPD, Anticancer Research, Vol.26, No.6A, 4073-4078, 2006.
欧文冊子 ● Kazuto Ohkura, Hideko Nagasawa, Yoshihiro Uto, Natsuko Okamura, Aya Murakami and Hitoshi Hori : The Role of Gc Protein Oligosaccharide Structure as a Risk Factor for COPD, Anticancer Research, Vol.26, No.6A, 4073-4078, 2006.

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