『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=148478)

EID=148478EID:148478, Map:0, LastModified:2014年2月17日(月) 11:50:51, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Miyoshi Atsushi (日) (読)
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2. (英) Kitajima Yoshihiko (日) (読)
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[継承]
3. (英) Ide Takao (日) (読)
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[継承]
4. (英) Ohtaka Kazuma (日) (読)
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5.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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6.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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7.堀 均
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[継承]
8. (英) Miyazaki Kohji (日) (読)
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題名 (必須): (英) Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tumor hypoxia has been reported to induce tumor progression in several carcinomas. Current studies have shown that hypoxia inducible factor-1alpha (HIF-1alpha) is stabilized under hypoxic conditions and transactivates various genes related to cancer aggressiveness. In the present study, we examined whether hypoxia affects cancer invasion in hepatocellular carcinoma. We aimed to solve the molecular mechanism of tumor invasion under the hypoxic condition. We showed that tumor hypoxia accelerated cancer invasion in two hepatoma cell lines. Using Western blot and RT-PCR analyses we demonstrated striking evidence that the expression of HIF-1alpha, ETS-1, MMP-7 and MT1-MMP was strongly upregulated by hypoxic stimulation. To examine whether these invasion-related genes are regulated by HIF-1alpha, we treated hepatoma cells with TX-402, which was reported to repress HIF-1alpha expression. HIF-1alpha expression was strongly repressed by the TX-402 treatment. In contrast, the expression of ETS-1, MMP-7 and MT1-MMP mRNA was not affected by TX-402 treatment. We further established stable transfectants in which HIF-1alpha dominant negative vector was introduced into Hep3B cells (pHIF-1alphaDN). In the pHIF-1alphaDN cells, the expression of ETS-1, MMP-7 and MT1-MMP was not repressed. Moreover, the invasion activity of pHIF-1alphaDN was not altered, compared with that of the mock. In hepatoma cells, we provided evidence that hypoxic stress accelerates cancer invasion by upregulating ETS-1 and the MMP family by an HIF-1alpha-independent pathway.  (日)    [継承]
キーワード (推奨): 1. (英) hypoxia (日) (読) [継承]
2. (英) HIF-1alpha (日) (読) [継承]
3. (英) invasion (日) (読) [継承]
4. (英) MMP (日) (読) [継承]
5. (英) hepatocellular carcinoma (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1019-6439
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 29 [継承]
(必須): 6 [継承]
(必須): 1533 1539 [継承]
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年月日 (必須): 西暦 2006年 12月 初日 (平成 18年 12月 初日) [継承]
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PMID (任意): 17088993    (→Scopusで検索) [継承]
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WOS (任意): 000242312100023 [継承]
Scopus (任意): 2-s2.0-33947302545 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Atsushi Miyoshi, Yoshihiko Kitajima, Takao Ide, Kazuma Ohtaka, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori and Kohji Miyazaki : Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner, International Journal of Oncology, Vol.29, No.6, 1533-1539, 2006.
欧文冊子 ● Atsushi Miyoshi, Yoshihiko Kitajima, Takao Ide, Kazuma Ohtaka, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori and Kohji Miyazaki : Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner, International Journal of Oncology, Vol.29, No.6, 1533-1539, 2006.

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