『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=148328)

EID=148328EID:148328, Map:0, LastModified:2012年11月4日(日) 21:34:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[馬渡 一諭], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.河野 崇
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.大下 修造
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.髙橋 章 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tsutsumi Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.富山 芳信 ([徳島大学.病院.中央診療施設等.手術部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.中屋 豊
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Ketamine inhibits adenosine triphosphate-sensitive potassium (KATP) channels, which results in the blocking of ischemic preconditioning in the heart and inhibition of vasorelaxation induced by KATP channel openers. In the current study, the authors investigated the molecular mechanisms of ketamine's actions on sarcolemmal KATP channels that are reassociated by expressed subunits, inwardly rectifying potassium channels (Kir6.1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B). The authors used inside-out patch clamp configurations to investigate the effects of ketamine on the activities of reassociated Kir6.0/SUR channels containing wild-type, mutant, or chimeric SURs expressed in COS-7 cells. Ketamine racemate inhibited the activities of the reassociated KATP channels in a SUR subtype-dependent manner: SUR2A/Kir6.2 (IC50 = 83 microM), SUR2B/Kir6.1 (IC50 = 77 microM), SUR2B/Kir6.2 (IC50 = 89 microM), and SUR1/Kir6.2 (IC50 = 1487 microM). S-(+)-ketamine was significantly less potent than ketamine racemate in blocking all types of reassociated KATP channels. The ketamine racemate and S-(+)-ketamine both inhibited channel currents of the truncated isoform of Kir6.2 (Kir6.2DeltaC36) with very low affinity. Application of 100 mum magnesium adenosine diphosphate significantly enhanced the inhibitory potency of ketamine racemate. The last transmembrane domain of SUR2 was essential for the full inhibitory effect of ketamine racemate. These results suggest that ketamine-induced inhibition of sarcolemmal KATP channels is mediated by the SUR subunit. These inhibitory effects of ketamine exhibit specificity for cardiovascular KATP channels, at least some degree of stereoselectivity, and interaction with intracellular magnesium adenosine diphosphate.  (日)    [継承]
キーワード (推奨): 1. (英) ATP-Binding Cassette Transporters (日) (読) [継承]
2. (英) Adenosine Diphosphate (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) COS Cells (日) (読) [継承]
5. (英) Cercopithecus aethiops (日) (読) [継承]
6. (英) DNA, Complementary (日) (読) [継承]
7. (英) Excitatory Amino Acid Antagonists (日) (読) [継承]
8. (英) KATP Channels (日) (読) [継承]
9. (英) Ketamine (日) (読) [継承]
10. (英) Mutation (日) (読) [継承]
11. (英) Patch-Clamp Techniques (日) (読) [継承]
12. (英) Potassium Channel Blockers (日) (読) [継承]
13. (英) Potassium Channels (日) (読) [継承]
14. (英) Potassium Channels, Inwardly Rectifying (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Recombinant Fusion Proteins (日) (読) [継承]
17. (英) Sarcolemma (日) (読) [継承]
18. (英) Stereoisomerism (日) (読) [継承]
19. (英) Transfection (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 102 [継承]
(必須): 1 [継承]
(必須): 93 101 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 1月 初日 (平成 17年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200501000-00017    (→Scopusで検索) [継承]
PMID (任意): 15618792    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan. haf2670@ams.odn.ne.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Kawano, Shuzo Oshita, Akira Takahashi, Y Tsutsumi, Katsuya Tanaka, Yoshinobu Tomiyama, Hiroshi Kitahata and Yutaka Nakaya : Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology, Vol.102, No.1, 93-101, 2005.
欧文冊子 ● Takashi Kawano, Shuzo Oshita, Akira Takahashi, Y Tsutsumi, Katsuya Tanaka, Yoshinobu Tomiyama, Hiroshi Kitahata and Yutaka Nakaya : Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology, Vol.102, No.1, 93-101, 2005.

関連情報

Number of session users = 0, LA = 1.38, Max(EID) = 360825, Max(EOID) = 966461.