『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=147728EID:147728, Map:0, LastModified:2012年11月3日(土) 20:10:27, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[福井 誠], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.福井 誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学])
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学籍番号 (推奨):
[継承]
2.日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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学籍番号 (推奨):
[継承]
3.横山 正明
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学籍番号 (推奨):
[継承]
4.田部 慎一
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学籍番号 (推奨):
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5.吉岡 昌美
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題名 (必須): (英) Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The aim of this study was to identify salivary immunoglobulin A (IgA) directed to oral microbial GroEL in patients with periodontitis and to demonstrate their potential protective role through a reduction of inflammatory cytokine production induced by microbial GroEL. Using five different proteins belonging to the heat-shock protein 60 family, Western immunoblot analysis of salivary IgA from 63 subjects revealed immunoreactivities with Campylobacter rectus GroEL and Porphyromonas gingivalis GroEL in subjects with periodontitis (P < 0.05) compared to control subjects. Using the BIACORE 1000 to measure the salivary IgA titers directed towards C. rectus GroEL, high resonance unit (RU) values were observed in the saliva samples from patients with periodontitis (P < 0.01). Furthermore, the number of teeth with deep pocket depth (>or=5 mm) showed a high correlation coefficient with the RU value (r = 0.50, P < 0.01). C. rectus GroEL possessed the ability to stimulate the production of interleukin-6 by gingival fibroblasts. Interestingly, salivary IgA antibody directed to C. rectus GroEL caused a partial inhibition of interleukin-6 production. This study showed a relationship between high levels of salivary IgA directed to GroEL and periodontal disease severity. Although additional investigations are required, salivary IgA to GroEL may have a protective role by reducing the inflammatory response induced by GroEL derived from periodontopathogenic bacteria.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Antigen-Antibody Reactions (日) (読) [継承]
3. (英) Antigens, Bacterial (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Campylobacter rectus (日) (読) [継承]
6. (英) Case-Control Studies (日) (読) [継承]
7. (英) Chaperonin 60 (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Immunoglobulin A, Secretory (日) (読) [継承]
11. (英) Interleukin-6 (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Periodontitis (日) (読) [継承]
15. (英) Saliva (日) (読) [継承]
16. (英) Salivary Proteins and Peptides (日) (読) [継承]
17. (英) Statistics, Nonparametric (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Microbiology and Immunology ([John Wiley & Sons, Inc.])
(pISSN: 0902-0055, eISSN: 1399-302X)

ISSN (任意): 0902-0055
ISSN: 0902-0055 (pISSN: 0902-0055, eISSN: 1399-302X)
Title: Oral microbiology and immunology
Title(ISO): Oral Microbiol. Immunol.
Publisher: Blackwell
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2006年 10月 初日 (平成 18年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1399-302X.2006.00290.x    (→Scopusで検索) [継承]
PMID (任意): 16922927    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Clinic of Preventive Dentistry, General Dentistry, The Tokushima University Hospital, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role., Oral Microbiology and Immunology, Vol.21, No.5, 289-295, 2006.
欧文冊子 ● Makoto Fukui, Daisuke Hinode, Masaaki Yokoyama, Shin-ichi Tanabe and Masami Yoshioka : Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role., Oral Microbiology and Immunology, Vol.21, No.5, 289-295, 2006.

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