『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=147279)

EID=147279EID:147279, Map:0, LastModified:2014年2月19日(水) 17:36:11, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.医学部.医科栄養学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Pike Wesley J. (日) (読)
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2. (英) Pathrose Peterman (日) (読)
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3. (英) Barmina Olga (日) (読)
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4. (英) Chang Ching-Yi (日) (読)
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[継承]
5. (英) McDonnell P. Donald (日) (読)
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6.山本 浩範
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7. (英) Shevde K. Nirupama (日) (読)
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題名 (必須): (英) Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription  (日)    [継承]
副題 (任意):
要約 (任意): (英) The vitamin D receptor (VDR) is known to mediate the biological actions of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) through its ability to regulate cellular programs of gene expression. We identified VDR- and retinoid X receptor (RXR)-interacting LXXLL peptides using a mammalian two-hybrid system and examined whether these molecules could block vitamin D and 9-cis retinoic acid (9-cis RA) response. Peptides were identified that were reactive to RXR alone as well as to both VDR and RXR. Peptide fusion proteins were then examined in MC3T3 E1 cells for their ability to block induction of the osteocalcin promoter by 1,25(OH)(2)D(3) or stimulation of an RARE-TK reporter by 9-cis RA. Peptides that interacted with both VDR and RXR blocked 1,25(OH)(2)D(3)-dependent transcription by up to 75%. Peptides that interacted with RXR blocked 9-cis RA induced transcription. Two RXR-interacting peptides, however, were also found to block 1,25(OH)(2)D(3) response effectively. These studies support the idea that comodulator recruitment is essential for VDR- and RXR-mediated gene expression and that RXR is required for 1,25(OH)(2)D(3)-induced osteocalcin gene transcription. This approach may represent a novel means of assessing the contribution of RXR in various endogenous biological responses to 1,25(OH)(2)D(3).  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) COS Cells (日) (読) [継承]
3. (英) Calcitriol (日) (読) [継承]
4. (英) Histone Acetyltransferases (日) (読) [継承]
5. (英) Nuclear Receptor Coactivator 1 (日) (読) [継承]
6. (英) Nuclear Receptor Coactivator 2 (日) (読) [継承]
7. (英) Oligopeptides (日) (読) [継承]
8. (英) Osteocalcin (日) (読) [継承]
9. (英) Receptors, Calcitriol (日) (読) [継承]
10. (英) Receptors, Retinoic Acid (日) (読) [継承]
11. (英) Retinoid X Receptors (日) (読) [継承]
12. (英) Transcription Factors (日) (読) [継承]
13. (英) Transcription, Genetic (日) (読) [継承]
14. (英) Transcriptional Activation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cellular Biochemistry ([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)

ISSN (任意): 0730-2312
ISSN: 0730-2312 (pISSN: 0730-2312, eISSN: 1097-4644)
Title: Journal of cellular biochemistry
Title(ISO): J Cell Biochem
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 252 258 [継承]
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年月日 (必須): 西暦 2003年 2月 1日 (平成 15年 2月 1日) [継承]
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DOI (任意): 10.1002/jcb.10336    (→Scopusで検索) [継承]
PMID (任意): 12520523    (→Scopusで検索) [継承]
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WOS (任意): 000180479100009 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, Non-P.H.S.  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● J. Wesley Pike, Peterman Pathrose, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Hironori Yamamoto and Nirupama K. Shevde : Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription, Journal of Cellular Biochemistry, Vol.88, No.2, 252-258, 2003.
欧文冊子 ● J. Wesley Pike, Peterman Pathrose, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Hironori Yamamoto and Nirupama K. Shevde : Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription, Journal of Cellular Biochemistry, Vol.88, No.2, 252-258, 2003.

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