『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=147003EID:147003, Map:0, LastModified:2012年11月17日(土) 18:59:35, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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[継承]
3. (英) Sakurai Yoshinori (日) (読)
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4.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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5.堀 均
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[継承]
6. (英) Nagata Kenji (日) (読)
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[継承]
7. (英) Suzuki Minoru (日) (読)
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[継承]
8. (英) Maruhashi Akira (日) (読)
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[継承]
9. (英) Kinashi Yuko (日) (読)
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[継承]
10. (英) Ono Koji (日) (読)
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題名 (必須): (英) The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy  (日)    [継承]
副題 (任意):
要約 (任意): (英) To evaluate the usefulness of a new 10B-compound (TX-2100) as a 10B-carrier in boron neutron capture therapy (BNCT), compared with the simultaneous use of its component drugs, sodium borocapate-10B (BSH) and 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide (TX-402). Further, the usefulness of mild temperature hyperthermia (MTH, 40 degrees Celsius, 30 min) combined with TX-2100 was also examined compared with MTH combined with the concurrent administration with its component drugs. TX-2100 is a hybrid compound that has both a hypoxic cytotoxin unit (TX-402) and a thermal neutron-sensitizing unit (BSH). TX-2100 or both TX-402 plus BSH in combination with MTH or not was administered to SCC VII tumour-bearing mice intra-peritoneally. Then, the 10B concentrations in the tumours and normal tissues were measured by gamma-ray spectrometry. Meanwhile, SCC VII tumour-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells in the tumours, then treated with TX-2100, TX-402 plus BSH or BSH only, in the same manner as in the biodistribution experiments, either with or without MTH. Right after thermal neutron irradiation during which intra-tumour 10B concentrations remained at similar levels, the tumours were excised, minced and trypsinized. The tumour cell suspensions thus obtained were incubated with cytochalasin-B (a cytokinesis blocker) and the micronucleus (MN) frequency in cells without BrdU labelling (=quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. Meanwhile, the MN frequency in the total (P + Q) tumour cell population was determined from the tumours that were not pre-treated with BrdU. The clonogenic cell survival was also determined in mice given no BrdU. 10B biodistribution analyses in tumours, brain, skin, muscles, blood and liver indicated that the administration of TX-2100 plus MTH is most favourable for concentrating a sufficient amount of 10B in tumours and maintaining a high enough 10B concentration during irradiation. In addition, MTH had a stronger sensitizing effect when combined with TX-2100 than with the concurrent administration of its components TX-402 and BSH on both the total and Q cell populations in solid tumours. MTH was very effective in combination with the newly-developed TX-2100. The sensitizing effect in combination with MTH should be examined when new 10B-carriers are designed.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Anoxia (日) (読) [継承]
3. (英) Borohydrides (日) (読) [継承]
4. (英) Boron Compounds (日) (読) [継承]
5. (英) Boron Neutron Capture Therapy (日) (読) [継承]
6. (英) Carcinoma, Squamous Cell (日) (読) [継承]
7. (英) Cell Proliferation (日) (読) [継承]
8. (英) Cell Survival (日) (読) [継承]
9. (英) Combined Modality Therapy (日) (読) [継承]
10. (英) Cyclic N-Oxides (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Fluorescent Antibody Technique (日) (読) [継承]
13. (英) Hyperthermia, Induced (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C3H (日) (読) [継承]
16. (英) Micronucleus Tests (日) (読) [継承]
17. (英) Quinoxalines (日) (読) [継承]
18. (英) Quinuclidines (日) (読) [継承]
19. (英) Sulfhydryl Compounds (日) (読) [継承]
20. (英) Time Factors (日) (読) [継承]
21. (英) Tissue Distribution (日) (読) [継承]
22. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Hyperthermia (Society for Thermal Medicine/European Society for Hyperthermic Oncology/Japanese Society for Thermal Medicine)
(pISSN: 0265-6736, eISSN: 1464-5157)

ISSN (任意): 0265-6736
ISSN: 0265-6736 (pISSN: 0265-6736, eISSN: 1464-5157)
Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Title(ISO): Int J Hyperthermia
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2006年 6月 1日 (平成 18年 6月 1日) [継承]
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DOI (任意): 10.1080/02656730600708171    (→Scopusで検索) [継承]
PMID (任意): 16754350    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Sennan-gun, Osaka, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshinori Sakurai, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi and Koji Ono : The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy, International Journal of Hyperthermia, Vol.22, No.4, 287-299, 2006.
欧文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshinori Sakurai, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi and Koji Ono : The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy, International Journal of Hyperthermia, Vol.22, No.4, 287-299, 2006.

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