『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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3. (英) Nagata Kenji (日) (読)
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4. (英) Suzuki Minoru (日) (読)
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5.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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6.堀 均
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7. (英) Kinashi Yuko (日) (読)
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8. (英) Ono Koji (日) (読)
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題名 (必須): (英) Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) The effect of vascular disrupting agent ZD6126 with time on the sensitivity to the hypoxic cytotoxin tirapazamine (TPZ) and gamma-rays was examined in large and small solid tumors. Mice bearing SCC VII tumors 1 or 1.5 cm in diameter received 5-bromo-2'-deoxyuridine (BrdU) continuously to label all proliferating (P) cells, followed by injection with or without ZD6126. In the absence of ZD6126, or 1 or 24 h following ZD6126 injection, the response to TPZ or gamma-ray irradiation in quiescent (Q) cells was assessed in terms of induced micronucleus (MN) frequency using immunofluorescence staining for BrdU. The MN frequency in the total cell population was determined from the tumors not pretreated with BrdU. Another group of tumor-bearing mice received a series of test doses of gamma-rays while alive or after tumor clamping to obtain hypoxic fractions (HFs) in the tumors. One hour after ZD6126 injection, both small and large tumors showed lower and higher sensitivity, and 24 h after, higher and lower sensitivity, to gamma-rays and TPZ, respectively, than the tumors not treated with ZD6126. Further, they showed larger and smaller HFs 1 and 24 h after ZD6126 injection, respectively. Without ZD6126 and 1 h after injection, small tumors were more sensitive to gamma-rays and less sensitive to TPZ than large tumors, probably due to the smaller HFs than large tumors. In contrast, 24 h after the injection, these differences in sensitivity and the HF between small and large tumors were reversed. The changes in sensitivity and the size of the HF were more marked in the total cell population than in Q cells. Following ZD6126 treatment, in terms of tumor control, especially large tumors and total tumor cell population, administering TPZ 1 h later and gamma-ray irradiation 24 h later were effective. Intratumor physiologic factors such as the size of the HF, depending on the time after ZD6126 injection, have to be taken into account when combining another treatment with ZD6126.  (日)    [継承]
キーワード (推奨): 1. (英) Angiogenesis Inhibitors (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Carcinoma, Squamous Cell (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Gamma Rays (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Organophosphorus Compounds (日) (読) [継承]
9. (英) Radiation-Sensitizing Agents (日) (読) [継承]
10. (英) Radiotherapy Dosage (日) (読) [継承]
11. (英) Time Factors (日) (読) [継承]
12. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cancer Research and Clinical Oncology (Deutsche Krebsgesellschaft e.V.)
(pISSN: 0171-5216, eISSN: 1432-1335)

ISSN (任意): 0171-5216
ISSN: 0171-5216 (pISSN: 0171-5216, eISSN: 1432-1335)
Title: Journal of cancer research and clinical oncology
Title(ISO): J. Cancer Res. Clin. Oncol.
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 1月 末日 (平成 19年 1月 末日) [継承]
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DOI (任意): 10.1007/s00432-006-0145-1    (→Scopusで検索) [継承]
PMID (任意): 16924543    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Kenji Nagata, Minoru Suzuki, Yoshihiro Uto, Hitoshi Hori, Yuko Kinashi and Koji Ono : Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells, Journal of Cancer Research and Clinical Oncology, Vol.133, No.1, 47-55, 2007.
欧文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Kenji Nagata, Minoru Suzuki, Yoshihiro Uto, Hitoshi Hori, Yuko Kinashi and Koji Ono : Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells, Journal of Cancer Research and Clinical Oncology, Vol.133, No.1, 47-55, 2007.

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