『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=146996EID:146996, Map:0, LastModified:2013年10月11日(金) 10:42:27, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
2. (英) Ae Shutaro (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Koyama Daisuke (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Sakakibara Mitsutoshi (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Otomo Naoki (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Otsuki Mamoru (日) (読)
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学籍番号 (推奨):
[継承]
7.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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学籍番号 (推奨):
[継承]
8. (英) Kirk L. Kenneth (日) (読)
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学籍番号 (推奨):
[継承]
9.堀 均
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity  (日)    [継承]
副題 (任意):
要約 (任意): (英) We designed and synthesized isoprene analogues of artepillin C, a major component of Brazilian propolis, and investigated the inhibitory activity on lipid peroxidation of rat liver mitochondria (RLM) and RLM toxicity based on isoprenomics. We succeeded in the synthesis of artepillin C isoprene analogues using regioselective prenylation within the range from 22% to 53% total yield. Reactivity of artepillin C and its isoprene analogues with ABTS (2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonate)) radical cations showed only a slight difference among the molecules. The isoprene side-chain elongation analogues of artepillin C showed almost the same inhibitory activity against RLM lipid peroxidation as artepillin C. Artepillin C and its isoprene analogues had very weak RLM uncoupling activity. Moreover, artepillin C and its isoprene analogues exhibited a lower inhibitory activity against adenosine 5'-triphosphate (ATP) synthesis by about two orders of magnitude than the effective inhibitory activity against RLM lipid peroxidation. From these results we conclude that artepillin C isoprene analogues could be potent lipid peroxidation inhibitors having low mitochondrial toxicity. We also conclude that elongation of the isoprene side chain of artepillin C to increase lipophilicity had little influence on the inhibitory activity toward RLM lipid peroxidation.  (日)    [継承]
キーワード (推奨): 1. (英) Adenosine Triphosphate (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Butadienes (日) (読) [継承]
4. (英) Drug Design (日) (読) [継承]
5. (英) Fatty Acids (日) (読) [継承]
6. (英) Hemiterpenes (日) (読) [継承]
7. (英) Lipid Peroxidation (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mitochondria, Liver (日) (読) [継承]
10. (英) Models, Chemical (日) (読) [継承]
11. (英) Pentanes (日) (読) [継承]
12. (英) Phenylpropionates (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Wistar (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Bioorganic & Medicinal Chemistry ([Elsevier Science])
(pISSN: 0968-0896, eISSN: 1464-3391)

ISSN (任意): 0968-0896
ISSN: 0968-0896 (pISSN: 0968-0896, eISSN: 1464-3391)
Title: Bioorganic & medicinal chemistry
Title(ISO): Bioorg. Med. Chem.
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
(必須): 16 [継承]
(必須): 5721 5728 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 8月 15日 (平成 18年 8月 15日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bmc.2006.04.015    (→Scopusで検索) [継承]
PMID (任意): 16697207    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000239472700033 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Intramural  (日)    [継承]

標準的な表示

和文冊子 ● Yoshihiro Uto, Shutaro Ae, Daisuke Koyama, Mitsutoshi Sakakibara, Naoki Otomo, Mamoru Otsuki, Hideko Nagasawa, Kenneth L. Kirk and Hitoshi Hori : Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity, Bioorganic & Medicinal Chemistry, Vol.14, No.16, 5721-5728, 2006.
欧文冊子 ● Yoshihiro Uto, Shutaro Ae, Daisuke Koyama, Mitsutoshi Sakakibara, Naoki Otomo, Mamoru Otsuki, Hideko Nagasawa, Kenneth L. Kirk and Hitoshi Hori : Artepillin C isoprenomics: design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity, Bioorganic & Medicinal Chemistry, Vol.14, No.16, 5721-5728, 2006.

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