『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1.矢野 聖二
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2.楊河 宏章 ([徳島大学.病院.中央診療施設等.総合臨床研究センター])
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3.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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4. (英) Mukaida Naofumi (日) (読)
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5. (英) Matsushima Kouji (日) (読)
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6.曽根 三郎
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題名 (必須): (英) T helper 2 cytokines differently regulate monocyte chemoattractant protein-1 production by human peripheral blood monocytes and alveolar macrophages  (日)    [継承]
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要約 (任意): (英) Th2 cytokines, such as IL-4, IL-10, and IL-13, suppress proinflammatory cytokine production by monocytes/macrophages. Since monocyte chemoattractant protein-1 (MCP-1) is presumed to play an important role in monocyte recruitment and activation during inflammatory and immune responses, we examined here the effects of these Th2 cytokines on MCP-1 production by human blood monocytes and alveolar macrophages. Unstimulated, highly purified blood monocytes did not produce MCP-1 spontaneously, while LPS treatment induced the production of MCP-1 and its mRNA expression. All Th2 cytokines tested suppressed LPS-induced MCP-1 production and its mRNA expression, although the suppressive effect of IL-13 was weaker than that of IL-4 or IL-10. In contrast, IL-10, but neither IL-4 nor IL-13, induced unstimulated peripheral blood monocytes to produce biologically active MCP-1 protein within 4 h, reaching a maximal level at 12 h. IL-10-induced MCP-1 production was reduced by pretreatment of IL-10 with anti-IL-10 Ab, negating the involvement of contaminated endotoxin. Moreover, IL-10 induced MCP-1 mRNA expression in unstimulated monocytes, independent of de novo protein synthesis. Furthermore, human alveolar macrophages produced MCP-1 spontaneously, and the production was inhibited by IL-4 or IL-13, but was augmented by IL-10. These findings suggest that IL-10 regulates MCP-1 production by monocytes/macrophages in a different way from other Th2 cytokines, such as IL-4 and IL-13, and contributes to host defense responses.  (日)    [継承]
キーワード (推奨): 1. (英) Cells, Cultured (日) (読) [継承]
2. (英) Chemokine CCL2 (日) (読) [継承]
3. (英) Cytokines (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) Leukocytes (日) (読) [継承]
6. (英) Macrophages, Alveolar (日) (読) [継承]
7. (英) Monocytes (日) (読) [継承]
8. (英) Th2 Cells (日) (読) [継承]
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誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
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(必須): 157 [継承]
(必須): 6 [継承]
(必須): 2660 2665 [継承]
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年月日 (必須): 西暦 1996年 9月 15日 (平成 8年 9月 15日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8805671&dopt=Abstract [継承]
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PMID (任意): 8805671    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Seiji Yano, Hiroaki Yanagawa, Yasuhiko Nishioka, Naofumi Mukaida, Kouji Matsushima and Saburo Sone : T helper 2 cytokines differently regulate monocyte chemoattractant protein-1 production by human peripheral blood monocytes and alveolar macrophages, The Journal of Immunology, Vol.157, No.6, 2660-2665, 1996.
欧文冊子 ● Seiji Yano, Hiroaki Yanagawa, Yasuhiko Nishioka, Naofumi Mukaida, Kouji Matsushima and Saburo Sone : T helper 2 cytokines differently regulate monocyte chemoattractant protein-1 production by human peripheral blood monocytes and alveolar macrophages, The Journal of Immunology, Vol.157, No.6, 2660-2665, 1996.

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