『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=146233)

EID=146233EID:146233, Map:0, LastModified:2012年10月24日(水) 20:20:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1.青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
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2.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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3. (英) Inayama Mami (日) (読)
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4.岸 潤
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5. (英) Ugai Momoyo (日) (読)
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6.上原 久典 ([徳島大学.病院.中央診療施設等.病理部])
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7.泉 啓介
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8.曽根 三郎
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題名 (必須): (英) Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Imatinib mesylate is a potent and specific tyrosine kinase inhibitor against c-ABL, BCR-ABL, and c-KIT, and has been demonstrated to be highly active in chronic myeloid leukemia and gastrointestinal stromal tumors. We examined the antifibrotic effects of imatinib using a bleomycin-induced lung fibrosis model in mice because imatinib also inhibits tyrosine kinase of platelet-derived growth factor receptors (PDGFRs). Imatinib inhibited the growth of primary murine lung fibroblasts and the autophosphorylation of PDGFR-beta induced by PDGF. Administration of imatinib significantly prevented bleomycin-induced pulmonary fibrosis in mice, partly by reducing the number of mesenchymal cells incorporating bromodeoxyuridine. Analysis of bronchoalveolar lavage cells demonstrated that imatinib did not suppress early inflammation on Days 7 and 14 caused by bleomycin. These results suggest that imatinib has the potential to prevent pulmonary fibrosis by inhibiting the proliferation of mesenchymal cells, and that imatinib might be useful for the treatment of pulmonary fibrosis in humans.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bleomycin (日) (読) [継承]
3. (英) Bronchoalveolar Lavage Fluid (日) (読) [継承]
4. (英) Disease Models, Animal (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Fibroblasts (日) (読) [継承]
7. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Piperazines (日) (読) [継承]
11. (英) Pulmonary Fibrosis (日) (読) [継承]
12. (英) Pyrimidines (日) (読) [継承]
13. (英) Reference Values (日) (読) [継承]
14. (英) Treatment Outcome (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2005年 6月 1日 (平成 17年 6月 1日) [継承]
URL (任意):
DOI (任意): 10.1164/rccm.200404-531OC    (→Scopusで検索) [継承]
PMID (任意): 15735062    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine and Molecular Therapeutics, Course of Medical Oncology, University of Tokushima School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshinori Aono, Yasuhiko Nishioka, Mami Inayama, Jun Kishi, Momoyo Ugai, Hisanori Uehara, Keisuke Izumi and Saburo Sone : Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice, American Journal of Respiratory and Critical Care Medicine, Vol.171, No.11, 1279-1285, 2005.
欧文冊子 ● Yoshinori Aono, Yasuhiko Nishioka, Mami Inayama, Jun Kishi, Momoyo Ugai, Hisanori Uehara, Keisuke Izumi and Saburo Sone : Imatinib as a Novel Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice, American Journal of Respiratory and Critical Care Medicine, Vol.171, No.11, 1279-1285, 2005.

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