『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shigekiyo T. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kanazuka M. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.東 博之
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学籍番号 (推奨):
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4. (英) Ohshima T. (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kusaka K. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Saito S. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Congenital deficiency of histidine-rich glycoprotein: failure to identify abnormalities in routine laboratory assays of hemostastic function,immunologic function, and trace elements  (日)    [継承]
副題 (任意):
要約 (任意): (英) Histidine-rich glycoprotein (HRGP) has many biologic activities, but its physiologic function is still unclear. To show the physiologic function of HRGP, we studied five patients with congenital HRGP deficiency. Hemostatic screening tests, activities of natural anticoagulants and fibrinolytic proteins, markers of thrombin and plasmin generation, plasma levels of platelet-specific proteins, thrombin times with various concentrations of bovine thrombin, prolongation of thrombin time after addition of heparin or demartan sulfate, and contact activation of blood coagulation were normal or nearly normal in these patients. Serum concentrations of immunoglobulin, functional activity of the classical and the alternative pathway of complement, lymphocyte subsets, and serum concentrations of soluble interleukin-2 receptor were approximately normal in all patients, and serum concentrations of copper and zinc were completely normal. These results suggest that the physiologic functions of HRGP are limited when compared with its biologic activities. However, because the patients examined had plasma HRGP levels of 20% to 35% of normal, it is possible that 20% of normal HRGP level is sufficient for its physiologic functions.  (日)    [継承]
キーワード (推奨): 1. (英) Antigens, CD (日) (読) [継承]
2. (英) Blood Proteins (日) (読) [継承]
3. (英) Copper (日) (読) [継承]
4. (英) Diagnostic Tests, Routine (日) (読) [継承]
5. (英) Hemostasis (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Immunoglobulins (日) (読) [継承]
8. (英) Lymphocyte Count (日) (読) [継承]
9. (英) Lymphocyte Subsets (日) (読) [継承]
10. (英) Proteins (日) (読) [継承]
11. (英) Reference Values (日) (読) [継承]
12. (英) Trace Elements (日) (読) [継承]
13.亜鉛 (zinc) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Laboratory and Clinical Medicine (The Central Society for Clinical Research)
(pISSN: 0022-2143, eISSN: 1532-6543)

ISSN (任意): 0022-2143
ISSN: 0022-2143 (pISSN: 0022-2143, eISSN: 1532-6543)
Title: The Journal of laboratory and clinical medicine
Title(ISO): J Lab Clin Med
Publisher: Mosby Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 125 [継承]
(必須): 6 [継承]
(必須): 719 723 [継承]
都市 (任意):
年月日 (必須): 西暦 1995年 6月 初日 (平成 7年 6月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 7769366    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T. Shigekiyo, M. Kanazuka, Hiroyuki Azuma, T. Ohshima, K. Kusaka and S. Saito : Congenital deficiency of histidine-rich glycoprotein: failure to identify abnormalities in routine laboratory assays of hemostastic function,immunologic function, and trace elements, The Journal of Laboratory and Clinical Medicine, Vol.125, No.6, 719-723, 1995.
欧文冊子 ● T. Shigekiyo, M. Kanazuka, Hiroyuki Azuma, T. Ohshima, K. Kusaka and S. Saito : Congenital deficiency of histidine-rich glycoprotein: failure to identify abnormalities in routine laboratory assays of hemostastic function,immunologic function, and trace elements, The Journal of Laboratory and Clinical Medicine, Vol.125, No.6, 719-723, 1995.

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