『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=145913EID:145913, Map:0, LastModified:2019年1月31日(木) 10:59:28, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ohara T (日) (読)
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2. (英) Shirakami A (日) (読)
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学籍番号 (推奨):
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3.東 博之
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4. (英) Miura S (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Saito S (日) (読)
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学籍番号 (推奨):
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題名 (必須): (英) Binding of plasma fibronection to human polymorphonuclear leukocytes in normal subjects and patients with aplastic anemia and thyroid dysfunction  (日)    [継承]
副題 (任意):
要約 (任意): (英) The binding of iodine 125-labeled fibronectin to polymorphonuclear leukocytes (PMNs) from human peripheral blood was examined. The optimum temperature and time for the binding were 37 degrees C and 30 minutes, respectively. On increase in the amount of 125I-labeled fibronectin, its binding to PMNs became saturated. Scatchard analysis of data on binding indicated the presence of a single class of binding sites. PMNs from 15 normal subjects had approximately 6.3 +/- 1.6 x 10(3) sites per cell and a dissociation constant of 10.2 +/- 2.4 x 10(-9) mol/L, indicating that they had high affinity for soluble fibronectin. Arg-Gly-Asp-Ser inhibited the binding of fibronectin to PMNs, strongly suggesting that the fibronectin receptor is one of the Arg-Gly-Asp receptor family. The plasma level of fibronectin was higher in patients with hyperthyroidism and lower in patients with hypothyroidism than in normal subjects, without any significant change in the number of fibronectin binding sites of the PMNs. However, the number of binding sites of fibronectin on PMNs of patients with aplastic anemia was increased, probably because of sensitization of the PMNs with immune complex and other factors.  (日)    [継承]
キーワード (推奨): 1. (英) Anemia, Aplastic (日) (読) [継承]
2. (英) Fibronectins (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Kinetics (日) (読) [継承]
5. (英) Neutrophils (日) (読) [継承]
6. (英) Oligopeptides (日) (読) [継承]
7. (英) Receptors, Fibronectin (日) (読) [継承]
8. (英) Receptors, Immunologic (日) (読) [継承]
9.温度 (temperature) [継承]
10. (英) Thyroid Diseases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Laboratory and Clinical Medicine (The Central Society for Clinical Research)
(pISSN: 0022-2143, eISSN: 1532-6543)

ISSN (任意): 0022-2143
ISSN: 0022-2143 (pISSN: 0022-2143, eISSN: 1532-6543)
Title: The Journal of laboratory and clinical medicine
Title(ISO): J Lab Clin Med
Publisher: Mosby Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 113 [継承]
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(必須): 229 234 [継承]
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年月日 (必須): 西暦 1989年 2月 初日 (平成 元年 2月 初日) [継承]
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PMID (任意): 2521665    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Ohara, A Shirakami, Hiroyuki Azuma, S Miura and S Saito : Binding of plasma fibronection to human polymorphonuclear leukocytes in normal subjects and patients with aplastic anemia and thyroid dysfunction, The Journal of Laboratory and Clinical Medicine, Vol.113, No.2, 229-234, 1989.
欧文冊子 ● T Ohara, A Shirakami, Hiroyuki Azuma, S Miura and S Saito : Binding of plasma fibronection to human polymorphonuclear leukocytes in normal subjects and patients with aplastic anemia and thyroid dysfunction, The Journal of Laboratory and Clinical Medicine, Vol.113, No.2, 229-234, 1989.

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