| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yoshikawa Shuji (日) (読)
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| 2. | (英) Kamada Masaharu (日) (読)
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| 3. | 前川 正彦
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| 4. | 山本 哲史
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| 5. | 苛原 稔
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| 6. | 山野 修司
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| 7. | 青野 敏博
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| 8. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 9. | (英) Koide S Samuel (日) (読)
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| ○題名 (必須): | □ | (英) Hormonal Control of mRNA Expression of Immunoglobulin Binding Factor in Uterine Cervix (日)
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| ○要約 (任意): | □ | (英) Uterine cervical mucus contains an immunoglobulin binding factor (IgBF). It may play a role in preventing antibody production against sperm in the female reproductive tract. To elucidate the mechanism involved in the production of activated IgBF, we determined the effects of hormones on the expression of mRNAs of IgBF and of protein disulfide isomerase (PDI), activating enzyme, in uterine cervix by quantitative RT-PCR. The uterine cervices of female rats were excised at preovulatory, ovulatory, and postovulatory phases. The human uterine cervical adenocarcinoma cells (TCO-2) were cultured for 24 h in serum-free medium containing 17beta-estradiol or progesterone. Expression of IgBF and PDI mRNAs was significantly highest during the ovulatory phase. 17beta-estradiol stimulated the expression of both mRNAs in TCO-2; whereas progesterone was ineffective. In conclusion, estrogen regulates the production of IgBF by the endocervix and PDI in vivo, thereby increasing the level of activated IgBF in the female reproductive tract during the ovulatory phase, allowing sperm to enter the uterine cavity. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cervix Uteri (日) (読)
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| 3. | (英) Estradiol (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Gene Expression Regulation (日) (読)
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| 6. | (英) Humans (日) (読)
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| 7. | (英) In Situ Hybridization (日) (読)
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| 8. | (英) Lymphokines (日) (読)
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| 9. | (英) Progesterone (日) (読)
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| 10. | (英) Prostatic Secretory Proteins (日) (読)
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| 11. | (英) Protein Disulfide-Isomerases (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Rats (日) (読)
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| 14. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 15. | (英) Tumor Cells, Cultured (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 279
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 898 903
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 12月 29日 (平成 12年 12月 29日)
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| ○URL (任意): | □ | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11162446&dopt=Abstract
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| ○DOI (任意): | □ | 10.1006/bbrc.2000.4036 (→Scopusで検索)
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| ○PMID (任意): | □ | 11162446 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000166385900025
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| ○Scopus (任意): | □ | 2-s2.0-0034731493
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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