『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○共著種別 (推奨):
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○組織 (推奨):
○著者 (必須): 1. (英) Miyagawa Junichiro (日) (読)
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2.桒島 正道
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3. (英) Hanafusa Toshiaki (日) (読)
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4. (英) Ozaki K (日) (読)
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5. (英) Fujimura H (日) (読)
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6. (英) Ono Akira (日) (読)
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7. (英) Uenaka Rikako (日) (読)
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8. (英) Yamamoto Koji (日) (読)
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9. (英) Kaidoh M (日) (読)
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10. (英) Nikaido Hiroko (日) (読)
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11. (英) Hayakawa Junichiro (日) (読)
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12. (英) Horiuchi Masahisa (日) (読)
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13. (英) Saheki Takeyori (日) (読)
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14. (英) Matsuzawa Yuji (日) (読)
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○題名 (必須): □(英) Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) A mouse with juvenile visceral steatosis (the JVS mouse) has been recognized as a novel animal model for systemic carnitine deficiency. We examined cardiac, skeletal and smooth muscle cells in JVS and control mice by light and electron microscopy. Cardiac and skeletal muscle cells of these mice at 4 weeks of age exhibited a ragged-red appearance after trichrome staining. Electron microscopy, demonstrated increased numbers of mitochondria and lipid droplets in the cells. Compression or distortion of the myofibril bundles, primarily due to the increased number of mitochondria, suggests the possible existence of a functional disturbance of the cardiac and skeletal muscle. In the urinary bladder, only one or two large lipid droplets and slightly increased number of mitochondria were recognized in the perinuclear region of the smooth muscle cells. At 8 weeks of age, the mouse enzyme histochemistry specific for mitochondria, such as cytochrome c oxidase and succinic dehydrogenase, and oil red O staining, confirmed further increases in the number of mitochondria and lipid droplets in the heart. However, the accumulation of these organelles in the skeletal and smooth muscle cells was no greater than that noted in JVS mice at 4 weeks of age. In the cardiac muscle cells, autolysosomes or autophagic vacuoles containing electron-dense membranous, lamellar or whorled structures closely associated with mitochondria and pseudoinclusion bodies in the nucleus were recognized, and bundles of myofibrils were buried under numerous mitochondria, suggesting the existence of disturbed contractile function in the heart of JVS mice. These results indicate that this murine strain associated with systemic carnitine deficiency exhibits a generalized mitochondrial abnormality in the muscle system especially in the heart.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.カルニチン (carnitine) [継承]
3. (英) Fatty Liver (日) (読) [継承]
4. (英) Hyperlipoproteinemias (日) (読) [継承]
5. (英) Mice (日) (読) [継承]
6. (英) Mice, Mutant Strains (日) (読) [継承]
7. (英) Microscopy, Electron (日) (読) [継承]
8. (英) Mitochondria, Heart (日) (読) [継承]
9. (英) Muscle, Skeletal (日) (読) [継承]
10. (英) Muscles (日) (読) [継承]
11.心筋 (myocardium) [継承]
○発行所 (推奨):
○誌名 (必須): □Virchows Archiv (European Society of Pathology)
(pISSN: 0945-6317, eISSN: 1432-2307)

○ISSN (任意): □0945-6317
ISSN: 0945-6317 (pISSN: 0945-6317, eISSN: 1432-2307)
Title: Virchows Archiv : an international journal of pathology
Title(ISO): Virchows Arch
Supplier: Springer Online Journal Archive
Publisher: Springer
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○巻 (必須): □426 [継承]
○号 (必須): □3 [継承]
○頁 (必須): □271 279 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1995年 4月 初日 (平成 7年 4月 初日) [継承]
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○PMID (任意): □7773507    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Junichiro Miyagawa, Masamichi Kuwajima, Toshiaki Hanafusa, K Ozaki, H Fujimura, Akira Ono, Rikako Uenaka, Koji Yamamoto, M Kaidoh, Hiroko Nikaido, Junichiro Hayakawa, Masahisa Horiuchi, Takeyori Saheki and Yuji Matsuzawa : Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency, Virchows Archiv, Vol.426, No.3, 271-279, 1995.
欧文冊子 ● Junichiro Miyagawa, Masamichi Kuwajima, Toshiaki Hanafusa, K Ozaki, H Fujimura, Akira Ono, Rikako Uenaka, Koji Yamamoto, M Kaidoh, Hiroko Nikaido, Junichiro Hayakawa, Masahisa Horiuchi, Takeyori Saheki and Yuji Matsuzawa : Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency, Virchows Archiv, Vol.426, No.3, 271-279, 1995.

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