| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 大石 美佳
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| 2. | 堀部 ますみ
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| 3. | (英) Ikedo Dai (日) (読)
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| 4. | (英) Miyazaki M (日) (読)
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| 5. | 大石 慶二
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| 6. | 片岡 正俊
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| 7. | 木戸 淳一
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| 8. | 永田 俊彦
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| ○題名 (必須): | □ | (英) Effect of retinoic acid on osteopontin expression in rat clonal dental pulp cells (日)
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| ○要約 (任意): | □ | (英) We studied the effect of retinoic acid on osteopontin synthesis and the mRNA expression in rat clonal dental pulp cells, RPC-C2A. An immunoprecipitation assay clarified that retinoic acid caused an increase in phosphorylated osteopontin synthesis that was dose-dependent, and marked increases were observed at retinoic acid concentrations of 10(-6) to 10(-5) M (1.7-fold). A Northern blotting analysis revealed a similar pattern of increase in osteopontin mRNA expression of up to 6.2-fold of control levels. Because osteopontin has an important role in the mineralization process, these results suggest that retinoic acid regulates mineralization, which takes place in the pulp cavity, including reparative dentin formation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cells, Cultured (日) (読)
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| 3. | (英) Clone Cells (日) (読)
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| 4. | (英) Dental Pulp (日) (読)
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| 5. | (英) Dose-Response Relationship, Drug (日) (読)
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| 6. | (英) Gene Expression (日) (読)
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| 7. | (英) Osteopontin (日) (読)
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| 8. | (英) Phosphorylation (日) (読)
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| 9. | (英) RNA, Messenger (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Sialoglycoproteins (日) (読)
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| 12. | (英) Tooth Calcification (日) (読)
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| 13. | (英) Tretinoin (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Endodontics ([The American Association of Endodontics])
(pISSN: 0099-2399, eISSN: 1878-3554)
| ○ISSN (任意): | □ | 0099-2399
ISSN: 0099-2399
(pISSN: 0099-2399, eISSN: 1878-3554) Title: Journal of endodonticsTitle(ISO): J EndodPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 25
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 683 685
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1999年 10月 初日 (平成 11年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S0099-2399(99)80355-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 10687528 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0033202527
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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