『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=145001EID:145001, Map:0, LastModified:2017年5月17日(水) 14:53:48, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[新垣 尚捷], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Warn Richard (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Harvey Pascale (日) (読)
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[継承]
3. (英) Warn Alba (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Foley-Comer Adam (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Heldinc Paraskevi (日) (読)
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[継承]
6. (英) Versnel Marjan (日) (読)
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[継承]
7.新垣 尚捷
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学籍番号 (推奨):
[継承]
8. (英) Daikuhara Yasushi (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Laurent J. Geoffrey (日) (読)
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[継承]
10. (英) Herrick E. Sarah (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Mutsaers E. Steven (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Hgf/sf induces mesothelial cell migration and proliferation by autocrine and paracrine pathways  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mesothelial repair differs from that of other epithelial-like surfaces as healing does not occur solely by centripetal in-growth of cells as a sheet from the wound margins. Mesothelial cells lose their cell-cell junctions, divide, and adopt a fibroblast-like morphology while scattering across and covering the wound surface. These features are consistent with a cellular response to hepatocyte growth factor/scatter factor (HGF/SF). In this study, we examined the ability of mesothelial cells to secrete HGF/SF and investigated its possible role as an autocrine regulator of mesothelial cell motility and proliferation. We found that human primary mesothelial cells expressed HGF/SF mRNA and secreted active HGF/SF into conditioned medium as determined by ELISA and in a scattering bioassay. These cells also expressed the HGF/SF receptor, Met, as shown by RT-PCR and by Western blot analysis and immunofluorescence. Incubation of mesothelial cells with neutralizing antibodies to HGF/SF decreased cell migration to 25% of controls, whereas addition of HGF/SF disrupted cell-cell junctions and induced scattering and enhanced mesothelial cell migration. Furthermore, HGF/SF showed a small but significant mitogenic effect on all mesothelial cell lines examined. In conclusion, HGF/SF is produced by mesothelial cells and induces both motility and proliferation of these cells. These data are consistent with HGF/SF playing an autocrine role in mesothelial healing.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2. (英) Autocrine Communication (日) (読) [継承]
3. (英) Cell Division (日) (読) [継承]
4. (英) Cell Movement (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Epithelium (日) (読) [継承]
7. (英) Hepatocyte Growth Factor (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) Paracrine Communication (日) (読) [継承]
11. (英) Proto-Oncogene Proteins c-met (日) (読) [継承]
12. (英) Suramin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Experimental Cell Research ([Academic Press])
(pISSN: 0014-4827, eISSN: 1090-2422)

ISSN (任意): 0014-4827
ISSN: 0014-4827 (pISSN: 0014-4827, eISSN: 1090-2422)
Title: Experimental cell research
Title(ISO): Exp Cell Res
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 267 [継承]
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(必須): 258 266 [継承]
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年月日 (必須): 西暦 2001年 7月 15日 (平成 13年 7月 15日) [継承]
URL (任意):
DOI (任意): 10.1006/excr.2001.5240    (→Scopusで検索) [継承]
PMID (任意): 11426944    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-0035879092 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Richard Warn, Pascale Harvey, Alba Warn, Adam Foley-Comer, Paraskevi Heldinc, Marjan Versnel, Naokatu Arakaki, Yasushi Daikuhara, Geoffrey J. Laurent, Sarah E. Herrick and Steven E. Mutsaers : Hgf/sf induces mesothelial cell migration and proliferation by autocrine and paracrine pathways, Experimental Cell Research, Vol.267, No.2, 258-266, 2001.
欧文冊子 ● Richard Warn, Pascale Harvey, Alba Warn, Adam Foley-Comer, Paraskevi Heldinc, Marjan Versnel, Naokatu Arakaki, Yasushi Daikuhara, Geoffrey J. Laurent, Sarah E. Herrick and Steven E. Mutsaers : Hgf/sf induces mesothelial cell migration and proliferation by autocrine and paracrine pathways, Experimental Cell Research, Vol.267, No.2, 258-266, 2001.

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