『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Murdiastuti, Kwartarini (日) (読)
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2. (英) Purwanti, Nunuk (日) (読)
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3. (英) Karabasil, Ratko, Mileva (日) (読)
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4.李 雪飛
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5.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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6.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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7.金森 憲雄
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8.細井 和雄
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題名 (必須): (英) A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands  (日)    [継承]
副題 (任意):
要約 (任意): (英) A greater than twofold diversity in the expression level of aquaporin 5 (AQP5) has been observed in the membrane fraction of the submandibular gland (SMG) in Sprague-Dawley rats (Murdiastuti K, Miki O, Yao C, Parvin MN, Kosugi-Tanaka C, Akamatsu T, Kanamori N, and Hosoi K. Pflügers Arch 445: 405-412, 2002). In the present study, breeding between brother and sister rats was repeated within high AQP5 producers and low ones to obtain inbred offspring. High- and low-producer rats from 3rd to 18th generations were used for experiments. By Western blotting, levels of AQP5 proteins in the parotid and lacrimal glands, and lungs were all low in low producers, whereas they were all high in high producers, implying genetic variations of the gene for this water channel. Despite this implication, AQP5 mRNA levels were almost the same between the two groups by Northern blotting, suggesting the irrelevance of transcriptional regulation for this diversity. AQP5 cDNAs from the SMGs of the two groups were sequenced. The nucleotide sequence of AQP5 cDNA from low producers indicated the existence of a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the third transmembrane domain, but no alteration was detected in the Kozak area. The existence of such a mutation was confirmed by the assessment of genomic DNA also. This mutation may have resulted in an abnormal membrane insertion or ineffective trafficking of AQP5, since the rats having this mutation showed extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Aquaporin 5 (日) (読) [継承]
4. (英) Base Sequence (日) (読) [継承]
5. (英) Body Water (日) (読) [継承]
6. (英) Molecular Sequence Data (日) (読) [継承]
7. (英) Point Mutation (日) (読) [継承]
8. (英) Rats (日) (読) [継承]
9. (英) Salivary Glands (日) (読) [継承]
10. (英) Sequence Homology, Amino Acid (日) (読) [継承]
11. (英) Structure-Activity Relationship (日) (読) [継承]
発行所 (推奨): アメリカ生理学会 [継承]
誌名 (必須): American Journal of Physiology, Gastrointestinal and Liver Physiology ([アメリカ生理学会])
(pISSN: 0193-1857, eISSN: 1522-1547)

ISSN (任意): 0193-1857
ISSN: 0193-1857 (pISSN: 0193-1857, eISSN: 1522-1547)
Title: American journal of physiology. Gastrointestinal and liver physiology
Title(ISO): Am J Physiol Gastrointest Liver Physiol
Publisher: American Physiological Society
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(必須): 291 [継承]
(必須): 6 [継承]
(必須): GI1081 GI1088 [継承]
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年月日 (必須): 西暦 2006年 12月 初日 (平成 18年 12月 初日) [継承]
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DOI (任意): 10.1152/ajpgi.00449.2005    (→Scopusで検索) [継承]
PMID (任意): 16901987    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kwartarini Murdiastuti, Nunuk Purwanti, Mileva Ratko Karabasil, Xuefei Li, Chenjuan Yao, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi : A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.291, No.6, GI1081-GI1088, 2006.
欧文冊子 ● Kwartarini Murdiastuti, Nunuk Purwanti, Mileva Ratko Karabasil, Xuefei Li, Chenjuan Yao, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi : A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.291, No.6, GI1081-GI1088, 2006.

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